五種精油之成分分析及對馬拉色菌之抑制與抗發炎活性之研究

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Title:	五種精油之成分分析及對馬拉色菌之抑制與抗發炎活性之研究 Study on the compositions, anti-Malassezia furfur and anti-inflammatory activities of five essential oils 本研究探討五種精油，分別是檸檬香茅(Cymbopogon citratus)、百里香(Thymus vulgaris)、甜馬鬱蘭(Origanum majorana)、突尼西亞迷迭香(Rosmarinus officinalis)及西班牙迷迭香(Rosmarinus officinalis)之抑制馬拉色菌能力、抗菌交互作用、抗發炎及抑制脂解?的活性評估，並以氣相層析質譜儀(GC/MS)分析五種精油的成分。　　成分鑑定結果顯示，檸檬香茅精油主成分為geranial (41.66%)及neral (33.37%)；百里香精油主成分為thymol (43.56%)、cymene (32.29%)；甜馬鬱蘭精油主成分為terpinen-4-ol (41.01%)、cymene (11.02%)；突尼西亞迷迭香精油主成分為1,8-cineole (54.57%)、camphor (8.58%)、α-pinene (8.42%)；西班牙迷迭香精油主成分為1,8-cineole (38.26%)、α-pinene (22.41%)、camphor (10.45%)。　　抗菌活性部分，檸檬香茅精油抗馬拉色菌( Malassezia furfur )效果最好，MIC90為353.2 ?g/mL；抗發炎試驗部分顯示，NO自由基清除能力中，檸檬香茅精油效果最好，SC50濃度為0.33mg/mL，抑制5-LOX活性中，甜馬鬱蘭效果最好IC50為36.73?g/mL；脂解?(Lipase) 抑制活性能力中，甜馬鬱蘭精油效果最好，其IC50為46.60?g/mL。　　抗菌交互作用實驗中，檸檬香茅與甜馬鬱蘭組合、突尼西亞迷迭香與檸檬香茅組合、突尼西亞迷迭香與百里香組合以及西班牙迷迭香與百里香組合為無關性作用 (indifference)，其餘組合皆為累加作用(additive)。 This study investigated the anti-M. furfur properties, synergism effect, anti-inflammatory and lipase inhibitory activities of five essential oils, lemongrass (Cymbopogon citratus), thyme (Thymus vulgaris), sweet marjoram (Origanum majorana), Tunisian rosemary (Rosmarinus officinalis) and Spanish rosemary (Rosmarinus officinalis).The compositions of five essential oils were analyzed by gas chromatography mass spectrometry (GC/MS). 　　The results showed that the main components of lemongrass was geranial (41.66%) and neral (33.37%);thyme was thymol (43.56%)、cymene (32.29%);sweet marjoram was terpinen-4-ol (41.01%)、cymene (11.02%);Tunisian rosemary was 1,8-cineole (54.57%)、camphor (8.58%)、α-pinene (8.42%);and the Spanish rosemary was 1,8-cineole (38.26%)、α-pinene (22.41%)、camphor (10.45%).　　The lemongrass essential oil had the best anti-Malassezia furfur effect (MIC90 was 353.2 ?g/mL);and anti-inflammatory effect on NO free radical scavenging ability (SC50 was 0.33mg/mL).The sweet marjoram essential oil had the best effect on 5-LOX inhibitory activity (IC50 was 36.73?g/mL) and the lipase inhibitory activity (IC50 was 46.60?g/mL). 　　In the synergism effect test, the mixture of lemongrass and sweet marjoram, Tunisian rosemary and lemongrass, Tunisian rosemary and thyme, and Spanish rosemary and thyme were indifference, the other combinations were additive effect.
Authors:	李易修
Contributors:	化粧品應用與管理系蔡玫琳
Keywords:	精油馬拉色菌脂解? 協同作用抗發炎 essential oils Malassezia furfur lipase synergism effect anti- inflammatory
Date:	2020
Issue Date:	2022-10-21 10:32:15 (UTC+8)
Relation:	電子全文公開日期：2025-08-23 學年度：108， 116頁
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Dissertations and Theses

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