Secondary metabolites of Neosartorya fischeri inhibited fibroblast-mediated tumorigenensis in triple-negative breast cancer

CNU IR > Pharmacy and Science > 2017 > Item 310902800/33676

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Title:	Secondary metabolites of Neosartorya fischeri inhibited fibroblast-mediated tumorigenensis in triple-negative breast cancer
Authors:	張怡蓉黃靖雯謝正明梁雅婷李冠漢王嘉駿田孝威
Contributors:	生物科技系藥學系新藥創建研究中心美國南加州大學藥理暨藥物科學系) 美國南加州大學化學系
Keywords:	Triple-negative breast cancer fibroblast Neosartorya fischeri secondary metabolite
Date:	2017
Issue Date:	2022-01-25 15:07:11 (UTC+8)
Abstract:	Triple-negative breast cancer (TNBC), which is tested negative for estrogen receptor,progesterone receptor and HER2/neu receptor, is an aggressive histological subtype of breastcancer with limited choice of treatments. Epidermal growth factor receptor (EGFR) tyrosinekinase inhibitors (TKIs) have been studied to inhibit proliferation of TBNC, however, theylacked efficacy in clinical treatment. This may be due to cross-talk between cancer cells andneighboring stromal cells. For example, hepatocyte growth factor (HGF) secreted bycancer-associated fibroblasts has been shown to bind to a Met receptor and reduce efficiencyof TKIs in TNBC, indicating that microenvironment affected development of cancer cells. Tosurvey the effective TNBC inhibitors, we established a soft agar colony formation system forbreast cancer MDA-MB-468 cells with co-culture of fibroblasts. Neosartorya fischeri extractswere tested for their inhibitory activity on TNBC by applying to this system. The resultsshowed that some secondary metabolites of Neosartorya fischeri inhibitedfibroblast-mediated colony formation of MDA-MB-468 cells. One of these metabolitesexhibited inhibitory effect on phosphorylation of EGFR and Met, which offered the potentialas a chemotherapeutic agent for TNBC.
Relation:	2017 第十一屆嘉南藥理大學藥理學院師生研究成果發表會，起迄日：2017/05/02-2017/05/04
Appears in Collections:	[Pharmacy and Science] 2017 [Dept. of Pharmacy] Proceedings [Dept. of Biotechnology (including master's program)] Proceedings

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