固相微萃取結合直接探針熱脫附質譜法快速分析生物檢體中抗病毒用藥

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 食藥產業暨檢測科技系(含五專) > 科技部計畫 > Item 310902800/33567

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標題:	固相微萃取結合直接探針熱脫附質譜法快速分析生物檢體中抗病毒用藥 Simultaneous Analysis of Antiviral Drugs in Biological Matrics by Solid-Phase Microextraction Combined with Direct Probe Mass Spectrometry
作者:	鄭淨月
貢獻者:	嘉藥學校財團法人嘉南藥理大學醫藥化學系
關鍵字:	固相微萃取大氣游離質譜法生物檢體抗病毒用藥用藥依從性 Solid phase microextraction Ambient ionization tandem mass spectrometry Biological matrics Antiviral drug Adherence
日期:	2020
上傳時間:	2022-01-13 16:21:51 (UTC+8)
摘要:	對長期用藥依從性不足是一個具有財務和人類健康後果的深遠問題。低依從性是長期治療失敗的主要原因。但是，為監測長期用藥依從性開發的LC-MS分析方法既複雜又昂貴。本研究開發了以固相微萃取技術結合熱脫附電噴灑質譜法（SPME-TD-ESI / MS）的依從性監測的簡單方法。該方法僅需數微升樣品，不須樣品前處理。這種方法有望擴展到各種慢性病用藥監測，成為醫療單位的常規之醫學檢驗技術。 Inadequate adherence to long-term medication is a far-reaching issue with financial and human health. Low adherence is a major cause of long-term treatment failure. However, LC-MS analysis methods developed to monitor long-term medication adherence are both complex and expensive. This study developed a simple method-solid-phase microextraction combined with thermal desorption electrospray mass spectrometry (SPME-TD-ESI / MS) for monitoring adherence. This method requires only a few microliters of sample and does not require sample preparation. This method is expected to be extended to the monitoring of various chronic disease and become a routine medical test technology for medical units.
關聯:	計畫編號：MOST109-2635-M041-001 計畫年度：109 執行起迄：2020-08~2021-07
顯示於類別:	[食藥產業暨檢測科技系(含五專)] 科技部計畫

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