對長期用藥依從性不足是一個具有財務和人類健康後果的深遠問題。低依從性是長期治療失敗的主要原因。但是，為監測長期用藥依從性開發的LC-MS分析方法既複雜又昂貴。本研究開發了以固相微萃取技術結合熱脫附電噴灑質譜法（SPME-TD-ESI / MS）的依從性監測的簡單方法。該方法僅需數微升樣品，不須樣品前處理。這種方法有望擴展到各種慢性病用藥監測，成為醫療單位的常規之醫學檢驗技術。 Inadequate adherence to long-term medication is a far-reaching issue with financial and human health. Low adherence is a major cause of long-term treatment failure. However, LC-MS analysis methods developed to monitor long-term medication adherence are both complex and expensive. This study developed a simple method-solid-phase microextraction combined with thermal desorption electrospray mass spectrometry (SPME-TD-ESI / MS) for monitoring adherence. This method requires only a few microliters of sample and does not require sample preparation. This method is expected to be extended to the monitoring of various chronic disease and become a routine medical test technology for medical units.
