本發明有關於一種含實心乳膠顆粒及空心乳膠顆粒之核殼結構藥物緩釋纖維及其製備方法,其包括一核層,係設有複數個空心乳膠顆粒以承載一負載物;以及至少一殼層,係設有複數個實心乳膠顆粒或空心乳膠顆粒以包覆核層;藉此,本發明可利用空心乳膠顆粒承載藥物,使藥物由核層擴散進入殼層,再由殼層擴散至外界,達到延長藥物釋放之目的。 The invention relates to a drug sustained-release fiber having core-shell structure containing solid latex particles and hollow latex particles and a method for making the same. The drug sustained-release fiber having core-shell structure containing solid latex particles and hollow latex particles comprises a core layer having plural hollow latex particles for carrying a substance; and at least one shell layer having plural solid latex particles or the plural hollow latex particles for covering the core layer. Accordingly, the present invention can carry drugs by the plural hollow latex particles and allow the drugs to diffuse from the core layer having the plural hollow latex particles into the shell layer having the plural solid latex particles and then diffuses to the outside to achieve the purpose of prolonging the release of the drugs.