本發明有關於一種環氧化酶-2抑制劑及含此之醫藥組成物暨其應用。前述環氧化酶-2抑制劑包含8-羥基異黃酮苷素作為有效成分。前述醫藥組成物包含有效劑量之8-羥基異黃酮苷素,可抑制或緩解與環氧化酶-2活性增加相關的疾病或症狀,並用於製備抑制環氧化酶-2活性之醫藥組成物的用途。 The present invention relates to a cyclooxygenase-2 (COX-2) inhibitor and a medicinal composition including the same. The COX-2 inhibitor includes 8-hydroxydaidzein (8-OHD) as an active ingredient. The medicinal composition including an effective dose of 8-OHD can beneficially inhibit COX-2 activity,for inhibiting or alleviating a disease or a syndrome associated with elevated COX-2 activity, thereby being applied on a use of preparation of the medical composition for inhibiting COX-2 activity.