Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/32774
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    標題: 包覆空心乳膠顆粒及實心乳膠顆粒之藥物緩釋型電紡纖維之製備及性質之研究(I)
    The Study of Manufacture and Properties of Drug Sustained Release Electrospun Fibers That Contain Hollow Latex Particles and Solid Latex Particles
    作者: 李佳芬
    貢獻者: 嘉南藥理大學化妝品應用與管理系(含化妝品科技碩士班)
    關鍵字: 溫度感應性
    空心乳膠顆粒
    實心乳膠顆粒
    藥物釋放
    靜電紡絲纖維
    thermosensitive
    hollow latex particles
    solid latex particles
    drug release
    electrosp
    日期: 2018
    上傳時間: 2020-11-16 15:07:26 (UTC+8)
    摘要: 本本計畫主要是合成出具有溫度感應性和具酸鹼感應性的poly(methacrylic acid-N-isopropylacrylamide))(poly(MAA-NIPAAm))空心乳膠顆粒(hollow latex particle)、poly(methyl methacrylate) (PMMA)實心乳膠顆粒，以及合成具溫度感應性的Poly(N-isopropylacrylamide-co-N-methylol acrylamide)(poly(NIPAAm-co-NMA)) copolymer，然後再以poly(NIPAAm-co-NMA)及chitosan作為基材，以單軸靜電紡絲法製備出內部包覆poly(MAA-NIPAAm) hollow latex particle及PMMA實心乳膠顆粒(PMMA latex)的「poly(NIPAAm-co-NMA)/poly(MAA-NIPAAm) hollow latex particle / 實心PMMA latex/chitosan」電紡纖維，並將模擬藥物(咖啡因)載入纖維中或poly(MAA-NIPAAm) hollow latex particle中，並探討各種實驗變因對於「poly(NIPAAm-co-NMA)/poly(MAA-NIPAAm) hollow latex particle /實心PMMA latex/chitosan」電紡纖維之型態結構、藥物釋放狀態以及各種性質的影響。
    The project mainly synthesizes temperature-sensitive and acid-base sensitive poly(methacrylic acid-N-isopropylacrylamide) hollow latex particles, poly(methyl methacrylate) solid latex particles, and synthetic temperature-sensitive Poly(N-isopropylacrylamide-co-N-methylol acrylamide) copolymer. Then, poly(NIPAAm-co-NMA) and chitosan were used as electrospinning substrates and used the method of uniaxial electrospinning to prepare “poly(NIPAAm- co-NMA)/poly(MAA-NIPAAm) hollow latex particle / solid PMMA latex/chitosan” electrospun fiber, which contained with poly(MAA-NIPAAm) hollow latex particle and PMMA solid latex particles. The model drug caffeine was loaded into the fiber or poly(MAA-NIPAAm) hollow latex particle, and investigted the effect of various experimental variables on the morphology and drug release status and various properties of "poly(NIPAAm-co-NMA)/poly(MAA-NIPAAm) hollow latex particle/ PMMA solid latex/chitosan" electrospun fiber.
    關聯: 計畫編號：MOST107-2637-E041-003
    計畫年度：107
    執行起迄：2018-08~2019-07
    显示于类别:[化妝品應用與管理系(所)] 科技部計畫

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