Serum vascular adhesion protein-1 is up-regulated in hyperglycemia and is associated with incident diabetes negatively

doi:10.1038/s41366-018-0172-4

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標題:	Serum vascular adhesion protein-1 is up-regulated in hyperglycemia and is associated with incident diabetes negatively
作者:	Kuo, Chun-Heng Jung-Nan Wei(魏榮男) Yang, Chung-Yi Ou, Horng-Yih Wu, Hung-Tsung Fan, Kang-Chih Wang, Shu-Huei Hua, Cyue-Huei Ching-Hsiang Hsiao(蕭景祥) Mei-Kuei Lee(李美貴) Li, Hung-Yuan
貢獻者:	Fu Jen Catholic Univ Hosp, Dept Internal Med Chia Nan Univ Pharm & Sci I Shou Univ, E Da Hosp, Dept Med Imaging Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Div Endocrinol & Metab, Dept Internal Med,Coll Med Taipei Med Univ, Grad Inst Metab & Obes Sci Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch Natl Taiwan Univ, Dept Anat & Cell Biol, Coll Med Natl Taiwan Univ Hosp, Div Clin Pathol, Yun Lin Branch Natl Taiwan Univ Hosp, Dept Internal Med
關鍵字:	SENSITIVE AMINE OXIDASE GLYCATION END-PRODUCTS GLUCOSE-TRANSPORT RISK EXPRESSION CONVERSION RECEPTOR MARKERS INDEX
日期:	2019-03
上傳時間:	2020-07-29 13:55:26 (UTC+8)
出版者:	NATURE PUBLISHING GROUP
摘要:	Background/objectives Vascular adhesion protein-1 (VAP-1) can enhance tissue glucose uptake in cell studies and normalize hyperglycemia in animal studies. However, serum VAP-1 concentration (sVAP-1) is higher in subjects with diabetes in cross-sectional studies. In this cohort study, we test our hypothesis that sVAP-1 is increased in prediabetes to counteract hyperglycemia and is associated with incident diabetes negatively. Subjects/methods From 2006 to 2012, 600 subjects without diabetes from Taiwan Lifestyle Study were included and followed regularly. Diabetes was diagnosed if FPG >= 126 mg/dL (7 mmol/L), 2-h plasma glucose (2hPG) during an oral glucose tolerance test (OGTT) >= 200 mg/dL (11.1 mmol/L), or hemoglobin A1c (HbA1c) >= 6.5%, or if the subject received anti-diabetic medications. Abdominal fat areas were measured by abdominal computed tomography and sVAP-1 was analyzed by ELISA. Results sVAP-1 was higher in subjects with prediabetes (p < 0.05) and increased during an OGTT (p <0 .001). Fasting sVAP-1 was associated with the response of sVAP-1 during an OGTT (p < 0.001). Besides, sVAP-1 was associated negatively with body mass index (BMI, r = -0.1449, p = 0.003), waist circumference (r = -0.1425, p = 0.004), abdominal visceral (r = -0.1457, p = 0.003), and subcutaneous (r = -0.1025, p = 0.035) fat areas, and serum high-sensitivity C-reactive protein (hsCRP) concentration (r = -0.2035, p < 0.0001), and positively with plasma adiponectin concentration (r = 0.2086, p < 0.0001), adjusted for age and gender. After 4.7 +/- 2.6 years, 73 subjects (12.2%) developed incident diabetes. High sVAP-1 predicted a lower incidence of diabetes, adjusted for age, gender, BMI, family history of diabetes, HbA1c, HOMA2-%B and HOMA2-IR (HR = 0.66, 95% CI = 0.50-0.88, p < 0.01). Conclusions sVAP-1 is increased in response to hyperglycemia. It is associated with obesity and serum hsCRP concentration negatively, and plasma adiponectin concentration positively. Besides, a high sVAP-1 is associated with a lower incidence of diabetes in human.
關聯:	International Journal of Obesity, v.43, n.3, pp.512-522
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