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| 標題: | Relationship between fasting plasma glucose and incidence of diabetes in children and adolescents |
| 作者: | Yang, C-Y
Li, H-Y
Sung, F-C
Tan, E. Chia-Hui
Jung-Nan Wei(魏榮男)
Chuang, L-M |
| 貢獻者: | E Da Hosp, Dept Med Imaging
I Shou Univ, Sch Med Int Student
Natl Taiwan Univ Hosp, Dept Med Imaging
Natl Taiwan Univ, Coll Med
Natl Taiwan Univ Hosp, Dept Internal Med
China Med Univ, Coll Publ Hlth, Inst Environm Hlth
Minist Hlth & Welf, Natl Res Inst Chinese Med
Natl Yang Ming Univ, Inst Hosp & Hlth Care Adm
Chia Nan Univ Pharm & Sci
Natl Taiwan Univ, Coll Med, Grad Inst Clin Med |
| 關鍵字: | RISK-FACTORS
LIFE-STYLE
CHILDHOOD
MELLITUS
POPULATION
PREVENTION
PREDICTION
OBESITY
TYPE-1
COMPLICATIONS |
| 日期: | 2019-05 |
| 上傳時間: | 2020-07-29 13:55:12 (UTC+8) |
| 出版者: | WILEY |
| 摘要: | Aim To investigate the appropriate fasting plasma glucose threshold by which to define prediabetes in children and adolescents, based on its ability to predict incident paediatric diabetes. Methods In a nationwide survey of diabetes and renal disease conducted between 1992 and 2000 in all school-aged children in Taiwan, those with abnormal results in repeated urine tests received further physical examination and blood tests. Students who had blood tests for at least two time points were selected for the present study (N = 12 119). The incidence of paediatric diabetes, adjusted hazard ratio and predictive power of fasting plasma glucose were analysed. Results The incidence of paediatric diabetes increased with increasing fasting plasma glucose levels. Groups with fasting plasma glucose >5.6 mmol/l had a higher adjusted hazard ratio. The adjusted hazard ratio of incident diabetes for participants with higher fasting plasma glucose rose continuously when using a higher threshold for fasting plasma glucose. The area under the receiver-operating characteristic curve for fasting plasma glucose was 0.628 for predicting paediatric diabetes. The association between fasting plasma glucose and incident paediatric diabetes and the area under the receiver-operating characteristic curve were similar in boys and girls and were higher in the age group 12-18 years. According to receiver-operating characteristic curve analysis, the optimal thresholds, sensitivity and specificity were 4.75 mmol/l, 65% and 51%, respectively, for those aged 6-11 years and 5.19 mmol/l, 60% and 73%, respectively, for those aged 12-18 years. Conclusion Fasting plasma glucose is associated with the incidence of paediatric diabetes. The results of the present study can be used as reference data to suggest a cut-off value to define paediatric prediabetes. |
| 關聯: | Diabetic Medicine, v.36, n.5, pp. 633-643 |
| 顯示於類別: | [職業安全衛生系(含防災所)] 期刊論文
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