Hazards of Stroke in Renal Transplant Recipients and Patients With End-Stage Renal Disease

doi:10.1016/j.transproceed.2019.01.138

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標題:	Hazards of Stroke in Renal Transplant Recipients and Patients With End-Stage Renal Disease
作者:	Cheng, Ching-Yao Hue-Yu Wang(王慧瑜) Liou, Wen-Shyong Wu, Ming-Ju Kao, Chia-Hung
貢獻者:	Taichung Vet Gen Hosp, Dept Pharm, Taichung, Taiwan China Med Univ, Sch Pharm Chi Mei Med Ctr, Dept Pharm Chia Nan Univ Pharm & Sci, Dept Pharm Taichung Vet Gen Hosp, Dept Internal Med, Div Nephrol Chung Shan Med Univ, Sch Med China Med Univ, Grad Inst Clin Med Sci, Coll Med Natl Chung Hsing Univ, Grad Inst Biomed Sci China Med Univ Hosp, Dept Nucl Med & PET Ctr Asia Univ, Dept Bioinformat & Med Engn
關鍵字:	RISK-FACTORS PEOPLE
日期:	2019-06
上傳時間:	2020-07-29 13:55:06 (UTC+8)
出版者:	ELSEVIER SCIENCE INC
摘要:	Background. Several comparison studies have suggested that kidney transplant (KT) could reduce stroke risk in patients with end-stage renal disease (ESRD). To avoid the selection criteria bias of using dialysis patients as control groups, we compared the risk of stroke between KT recipients and comparable propensity score-matched dialysis patients. Methods. We used Taiwan's National Health Insurance Research Database to identify patients with newly diagnosed ESRD between 2000 and 2009. We separated them into 2 groups: a KT group and a non-KT dialysis-only group. To evaluate the stroke outcome, we compared each patient with KT to a patient on dialysis without KT using propensity score matching. Results. In total, 2735 KT recipients and 10,940 propensity score-matched dialysis patients were identified. The incidence rates of overall stroke were 9.1 and 23.4 per 1000 person-years in KT recipients and non-KT dialysis patients. Compared with the propensity score-matched dialysis patients, the patients who received KT exhibited significantly lower overall stroke risk, hemorrhagic stroke, and ischemic stroke, the adjusted hazard ratios were 0.37 (95% CI, 0.31-0.45), 0.19 (95% CI, 0.12-0.29), and 0.46 (95% CI, 0.37-0.56), respectively (all P < .001). Conclusions. Through a propensity score-matched cohort, this study confirms that KT is associated with a reduced risk of stroke more than dialysis alone in patients with newly diagnosed ESRD.
關聯:	Transplantation Proceedings, v.51, n.5, pp.1402-1405
顯示於類別:	[藥學系(所)] 期刊論文

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