The burdens of tuberculosis on patients with malignancy: incidence, mortality and relapse

doi:10.1038/s41598-019-48395-8

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題名:	The burdens of tuberculosis on patients with malignancy: incidence, mortality and relapse
作者:	Shu, Chin-Chung Liao, Kuang-Ming Chen, Yi-Chen Wang, Jhi-Joung Chung-Han Ho(何宗翰)
貢獻者:	Natl Taiwan Univ Hosp, Dept Internal Med Natl Taiwan Univ, Coll Med Chi Mei Med Ctr, Dept Internal Med Chi Mei Med Ctr, Dept Med Res Southern Taiwan Univ Sci & Technol, Al Biomed Ctr Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth CareAdm
關鍵詞:	LUNG-CANCER PATIENTS ACTIVE TUBERCULOSIS RISK INFECTION TB MULTICENTER SURVIVAL
日期:	2019-08
上傳時間:	2020-07-29 13:54:56 (UTC+8)
出版者:	NATURE PUBLISHING GROUP
摘要:	Population with malignancy is growing worldwide; however, its tuberculosis (TB) burden including remains unclear regarding incidence, mortality, and relapse. We retrieved information and identified patients with malignancy and TB between 2000 and 2015 from the Taiwanese National Health Insurance reimbursement datasets, Taiwan cancer registry and death registration. We analyzed the incidence of new TB in patients with malignancy and their mortality as well as TB recurrence. During study period, we reviewed 1,105,009 patients after exclusion and among them, 19,906 had newly diagnosed TB. The TB incidence in cancer patients divided all TB events increased annually, from 3% in 2000 to 13% in 2015. The standard incidence rates (SIR) were highest in cancer of respiratory tract (5.45), hematology (3.70) and then head and neck area (2.58). The mortality directly due to TB was defined as 0.83% and all-cause mortality were approximately 10.5% at 3 months and 20.56% at 12 months. After completing TB treatment, recurrence was diagnosed in 626 (3.14%), and 1001 (5.03%) patients within the first and the first two years, respectively. In conclusion, the incidence of TB in patients with malignancy increase yearly as well as its proportion within overall cases. The twelve-month all-cause mortality during TB and the two-year recurrence are as high as 20.56% and 5.03%, respectively. It indicates the importance of this population in future TB control, especially for those with malignancy of respiratory tract, and hematology as well as head and neck area.
關聯:	Scientific Reports, v.9, n11901
顯示於類別:	[Dept. of Hospital and Health (including master's program)] Periodical Articles

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