Topically Applied Cross-Linked Hyaluronan Attenuates the Formation of Spinal Epidural Fibrosis in a Swine Model of Laminectomy

doi:10.1038/s41598-019-50882-x

Chia Nan University of Pharmacy & Science Institutional Repository > 環境永續暨休閒學院 > 運動管理系 > 期刊論文 > Item 310902800/32675

請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/32675

標題:	Topically Applied Cross-Linked Hyaluronan Attenuates the Formation of Spinal Epidural Fibrosis in a Swine Model of Laminectomy
作者:	Lin, Cheng-Li Jou, I-Ming Wu, Cheng-Yi Kuo, Yuh-Ruey Yang, Shih-Chieh Lee, Jung-Shun Tu, Yuan-Kun Chen, Sung-Ching Yi-Hung Huang(黃儀鴻)
貢獻者:	Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Orthopaed Surg Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Res Ctr Clin Med,Skeleton Mat & Biocompatibl Core I Shou Univ, E Da Hosp, Dept Orthopaed ChiaYi Christian Hosp, Dept Orthopaed Natl Cheng Kung Univ Hosp, Dept Surg, Div Neurosurg Maxigen Biotech Inc Chia Nan Univ Pharm & Sci, Dept Sports Management
關鍵字:	MATRIX METALLOPROTEINASES EXPRESSION CD44 ACID FIBROBLASTS MODULATORS MIGRATION CYTOKINES SURGERY SYSTEM
日期:	2019-10
上傳時間:	2020-07-29 13:54:49 (UTC+8)
出版者:	NATURE PUBLISHING GROUP
摘要:	Epidural fibrosis is an inevitable aspect of the postoperative healing process which is one of the causes of failed back surgery syndrome following spinal surgery. The aim of the present study was to examine the inhibitory effect of 1,4-butanediol diglycidyl ether-crosslinked hyaluronan (cHA) on spinal epidural fibrosis in a swine model. Epidural fibrosis was induced through conduction of hemi-laminotomy (L2 and L3) or laminectomy (L4 and L5), while Ll was assigned as the control group in six pigs. The cHA was applied to L3 and L5 surgical sites. MRI evaluation, histologic examination, expressions of matrix metalloproteinases (MMPs), and cytokines in scar tissue were assessed four months after surgery. cHA treatment significantly decreased the scar formation in both hemi-laminotomy and laminectomy sites. cHA also significantly increased MMP-3 and MMP-9 expression in scar tissue. Further, the epithelial-mesenchyma I transition -related factors (transforming growth factor-beta and vimentin) were suppressed and the anti-inflammatory cytokines (CD44 and interleukin-6) were increasingly expressed in cHA-treated sites. The current study demonstrated that cHA may attenuate spinal epidural fibrosis formation after laminectomy surgery by enhancing the expression of MMPs and anti-inflammatory pathways.
關聯:	Scientific Reports, v.9, 14613
顯示於類別:	[運動管理系] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
10.1038-s41598-019-50882-x.pdf		2856Kb	Adobe PDF	346	檢視/開啟
index.html		0Kb	HTML	982	檢視/開啟

在CNU IR中所有的資料項目都受到原著作權保護.

TAIR相關文章

資料載入中.....