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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32672

    標題: Increased risk for hypothyroidism associated with carbon monoxide poisoning: a nationwide population-based cohort study
    作者: Huang, Chien-Cheng
    Chung-Han Ho(何宗翰)
    Chen, Yi-Chen
    Hsu, Chien-Chin
    Lin, Hung-Jung
    Su, Shih-Bin
    Wang, Jhi-Joung
    Guo, How-Ran
    貢獻者: Chi Mei Med Ctr, Dept Emergency Med
    Natl Cheng Kung Univ, Dept Environm & Occupat Hlth, Coll Med
    Southern Taiwan Univ Sci & Technol, Dept Senior Serv
    Chi Mei Med Ctr, Dept Med Res
    Chia Nan Univ Pharm & Sci, Dept Pharm
    Southern Taiwan Univ Sci & Technol, Dept Biotechnol
    Taipei Med Univ, Dept Emergency Med
    Chi Mei Med Ctr, Dept Occupat Med
    Southern Taiwan Univ Sci & Technol, Dept Leisure Recreat & Tourism Management
    Southern Taiwan Univ Sci & Technol, Allied AI Biomed Ctr
    Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med
    日期: 2019-11
    上傳時間: 2020-07-29 13:54:41 (UTC+8)
    摘要: Carbon monoxide poisoning (COP) may cause injuries to the central nervous and endocrine systems, which might increase the risk of developing hypothyroidism. We wanted to evaluate the association between COP and the risk of developing hypothyroidism because epidemiological data on this potential association are limited. We conducted a nationwide population-based cohort study using the Nationwide Poisoning Database and identified 24,328 COP subjects diagnosed between 1999 and 2012. By matching the index date and age, we selected 72,984 non-COP subjects for comparison. Subjects with thyroid diseases and malignancy before 1999 were excluded. We followed up the two groups of subjects until 2013 and compared the risk of developing hypothyroidism. COP subjects had a significantly higher risk for hypothyroidism than non-COP subjects (adjusted hazard ratio [AHR]: 3.8; 95% confidence interval [CI]: 3.2-4.7) after adjusting for age, sex, underlying comorbidities, and monthly income, and the AHR was particular higher in subjects with diabetes mellitus, hyperlipidemia, and mental disorder. The increased risk was highest in the first month after COP (AHR: 41.0; 95% CI: 5.4-310.6), and the impact remained significant even after 4 years. In conclusion, COP was associated with an increased risk for hypothyroidism. Further studies regarding the underlying mechanisms are warranted.
    關聯: Scientific Reports, v.9, 16512
    Appears in Collections:[藥學系(所)] 期刊論文

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