資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://ir.cnu.edu.tw/handle/310902800/32670
|
| 標題: | Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM |
| 作者: | Yen, I-Weng
Lee, Chien-Nan
Lin, Ming-Wei
Fan, Kang-Chih
Jung-Nan Wei(魏榮男)
Chen, Kuan-Yu
Chen, Szu-Chi
Tai, Yi-Yun
Kuo, Chun-Heng
Lin, Chia-Hung
Hsu, Chih-Yao
Chuang, Lee-Ming
Lin, Shin-Yu
Li, Hung-Yuan |
| 貢獻者: | Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch, Hsinchu, Taiwan
Natl Taiwan Univ Hosp, Dept Obstet & Gynecol, Taipei, Taiwan
Chia Nan Univ Pharm & Sci, Tainan, Taiwan
Ansn Clin, Hsinchu, Taiwan
Cardinal Tien Hosp, Dept Internal Med, New Taipei, Taiwan
Fu Jen Catholic Univ Hosp, Dept Internal Med, New Taipei, Taiwan
Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan |
| 關鍵字: | BODY-MASS INDEX
INSULIN
INFLAMMATION |
| 日期: | 2019-12 |
| 上傳時間: | 2020-07-29 13:54:35 (UTC+8) |
| 出版者: | PUBLIC LIBRARY SCIENCE |
| 摘要: | Aim Overweight and obesity are important risk factors of gestational diabetes mellitus (GDM). Clustering of metabolic risk factors in early pregnancy may be a potential pathogenesis between the link of overweight/obesity and GDM. Since it remains unexplored, we investigated if overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM in this cohort study. Methods Total 527 women who visited National Taiwan University Hospital for prenatal care in between November 2013 to April 2018 were enrolled. Risk factors of GDM in the first prenatal visit (FPV) were recorded. Overweight/obesity was defined if body mass index.24 kg/m(2). GDM was diagnosed from the result of a 75g oral glucose tolerance test in 24-28 gestational weeks. Results Overweight/obesity was associated with clustering of metabolic risk factors of GDM, including high fasting plasma glucose, high HbA1c, insulin resistance, high plasma triglyceride and elevated blood pressure in FPV (p< 0.05). There was a positive relationship between the number of metabolic risk factors and the incidence of GDM (p < 0.05). The odds ratios of HbA1c and diastolic blood pressure were higher in overweight/obese women, compared with those in normal-weight women. Conclusions Overweight/obesity is associated with clustering of metabolic risk factors in early pregnancy, which is correlated with higher risk of GDM. Our findings suggest that metabolic risk factors during early pregnancy should be evaluated in overweight/obese women. |
| 關聯: | Plos One, v.14, n.12, e0225978 |
| 顯示於類別: | [職業安全衛生系(含防災所)] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| 10.1371-journal.pone.0225978.pdf | | 712Kb | Adobe PDF | 296 | 檢視/開啟 | | index.html | | 0Kb | HTML | 1229 | 檢視/開啟 |
|
在CNU IR中所有的資料項目都受到原著作權保護.
|
