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| 標題: | The Potential Role of Sulbactam and Cephalosporins Plus Daptomycin Against Daptomycin-Nonsusceptible VISA and H-VISA Isolates: An In Vitro Study |
| 作者: | Lai, Chih-Cheng
Chen, Chi-Chung
Lu, Ying-Chen
Tsuey-Pin Lin(林翠品)
Chen, Hung-Jui
Su, Bo-An
Chao, Chien-Ming
Chuang, Yin-Ching
Hung-Jen Tang(湯宏仁) |
| 貢獻者: | Kaohsiung Vet Gen Hosp, Dept Internal Med, Tainan Branch
Chi Mei Med Ctr, Dept Med Res
Natl Chiayi Univ, Dept Food Sci
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Chi Mei Med Ctr, Dept Med
Chi Mei Med Ctr, Dept Intens Care Med |
| 關鍵字: | vancomycin-intermediate resistant S
aureus
heterogeneous vancomycin-intermediate S
aureus
daptomycin
cephalosporin
sulbactam
synergism test |
| 日期: | 2019-12 |
| 上傳時間: | 2020-07-29 13:54:22 (UTC+8) |
| 出版者: | MDPI |
| 摘要: | This study assesses the synergistic effect of the combination of cephalosporins and sulbactam with daptomycin against daptomycin-nonsusceptible, vancomycin-intermediate resistant Staphylococcus aureus (VISA) or heterogeneous vancomycin-intermediate S. aureus (h-VISA) isolates. The in vitro activity of daptomycin against daptomycin-nonsusceptible VISA/h-VISA isolates after adding cephalosporins with or without sulbactam was evaluated. The MIC of daptomycin against the VISA/h-VISA isolates was reduced after adding cephalosporins to daptomycin. Except for one VISA and two h-VISA isolates, the other VISA/h-VISA isolates became daptomycin-susceptible (MICs <= 1 mg/L). After adding sulbactam to each daptomycin/cephalosporin combination, the MIC of daptomycin against the VISA/h-VISA isolates decreased for 5 (33.3%), 6 (40.0%), 6 (40.0%), and 6 (40.0%) isolates with the cefazolin, cefmetazole, cefotaxime, and cefepime combinations, respectively. Synergism using the checkerboard method was noted in 100% of cefazolin and cefotaxime combinations and 87% and 80% of cefmetazole and cefepime combinations for all the VISA and h-VISA isolates. With the addition of sulbactam, synergism was noted in 100% of cefazolin, cefmetazole, and cefotaxime combinations and 93% of the cefepime combinations for all the VISA and h-VISA isolates. Almost all the FICs for the three-drug combinations were lower than those for the two-drug combinations. Using time-killing methods, a synergistic effect against five h-VISA isolates was observed. A synergistic effect of daptomycin, sulbactam, and each cephalosporin was observed for all VISA isolates. In conclusion, the activity of daptomycin against daptomycin-nonsusceptible VISA/h-VISA isolates can be enhanced by adding cephalosporins, and partially further promoted by sulbactam. |
| 關聯: | Antibiotics-Basel, v.8, n.4, 184 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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