Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/32653
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    標題: Neuroprotective effect of tempeh against lipopolysaccharide-induced damage in BV-2 microglial cells
    作者: Hwang, Juen-Haur
    Shu-Jing Wu(吳淑靜)
    Wu, Po-Long
    Shih, Yong-Yao
    Chan, Yin-Ching
    貢獻者: Buddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Otolaryngol
    Tzu Chi Univ, Sch Med, Hualien
    Chia Nan Univ Pharm & Sci, Dept Nutr Hlth
    CPC Corp, Refining & Mfg Res Inst, Biotech Business Ctr
    Providence Univ, Dept Food & Nutr
    關鍵字: Tempeh
    GABA
    BV-2 cells
    Oxidative stress
    Inflammation
    Brain-derived neurotrophic factor
    日期: 2019-12
    上傳時間: 2020-07-29 13:53:51 (UTC+8)
    出版者: TAYLOR & FRANCIS LTD
    摘要: Objectives: This study evaluated the bioactive composition of tempeh products and examined the effects of tempeh on BV-2 microglial cell cytotoxicity, neurotrophic effects, and expression of inflammatory genes. Methods: Tempeh products included soybean fermented by Rhizopus, soybean fermented through cocultivation with Rhizopus and Lactobacillus, and red bean fermented through cocultivation with Rhizopus and Lactobacillus (RT-C). We analyzed the bioactive contents of tempeh extracts and evaluated the effects of tempeh water extract on lipopolysaccharide (LPS)-treated BV-2 cells. Results: The results showed that RT-C water extract had the highest concentrations of ?-aminobutyric acid (GABA) and anthocyanin. The tempeh water extracts, especially RT-C, reduced the formation of LPS-induced reactive oxygen species, downregulated the levels of nitric oxide synthase and phospho-cyclic-AMP response element-binding protein, and upregulated the expression of brain-derived neurotrophic factor (BDNF). Discussion: Our data demonstrate that RT-C has the highest concentrations of GABA and anthocyanin, more effectively reduces oxidative stress and inflammation, and increases the expression of BDNF in LPS-induced BV-2 cells.
    關聯: Nutritional Neuroscience, v.22, n.12, pp.840-849
    显示于类别:[保健營養系(所) ] 期刊論文

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