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https://ir.cnu.edu.tw/handle/310902800/32653
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| 標題: | Neuroprotective effect of tempeh against lipopolysaccharide-induced damage in BV-2 microglial cells |
| 作者: | Hwang, Juen-Haur
Shu-Jing Wu(吳淑靜)
Wu, Po-Long
Shih, Yong-Yao
Chan, Yin-Ching |
| 貢獻者: | Buddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Otolaryngol
Tzu Chi Univ, Sch Med, Hualien
Chia Nan Univ Pharm & Sci, Dept Nutr Hlth
CPC Corp, Refining & Mfg Res Inst, Biotech Business Ctr
Providence Univ, Dept Food & Nutr |
| 關鍵字: | Tempeh
GABA
BV-2 cells
Oxidative stress
Inflammation
Brain-derived neurotrophic factor |
| 日期: | 2019-12 |
| 上傳時間: | 2020-07-29 13:53:51 (UTC+8) |
| 出版者: | TAYLOR & FRANCIS LTD |
| 摘要: | Objectives: This study evaluated the bioactive composition of tempeh products and examined the effects of tempeh on BV-2 microglial cell cytotoxicity, neurotrophic effects, and expression of inflammatory genes. Methods: Tempeh products included soybean fermented by Rhizopus, soybean fermented through cocultivation with Rhizopus and Lactobacillus, and red bean fermented through cocultivation with Rhizopus and Lactobacillus (RT-C). We analyzed the bioactive contents of tempeh extracts and evaluated the effects of tempeh water extract on lipopolysaccharide (LPS)-treated BV-2 cells. Results: The results showed that RT-C water extract had the highest concentrations of ?-aminobutyric acid (GABA) and anthocyanin. The tempeh water extracts, especially RT-C, reduced the formation of LPS-induced reactive oxygen species, downregulated the levels of nitric oxide synthase and phospho-cyclic-AMP response element-binding protein, and upregulated the expression of brain-derived neurotrophic factor (BDNF). Discussion: Our data demonstrate that RT-C has the highest concentrations of GABA and anthocyanin, more effectively reduces oxidative stress and inflammation, and increases the expression of BDNF in LPS-induced BV-2 cells. |
| 關聯: | Nutritional Neuroscience, v.22, n.12, pp.840-849 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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