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| 標題: | Bloodstream infections in hospitalized adults with dengue fever: Clinical characteristics and recommended empirical therapy |
| 作者: | Syue, Ling-Shan
Hung-Jen Tang(湯宏仁)
Hung, Yuan-Pin
Chen, Po-Lin
Li, Chia-Wen
Li, Ming-Chi
Tsai, Pei-Fang
Liu, Ching-Chuan
Lee, Nan-Yao
Ko, Wen-Chien |
| 貢獻者: | Natl Cheng Kung Univ Hosp, Dept Internal Med
Natl Cheng Kung Univ Hosp, Ctr Infect Control
Chi Mei Med Ctr, Dept Med
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Minist Hlth & Welf, Dept Internal Med, Tainan Hosp
Natl Cheng Kung Univ Hosp, Dept Pathol
Natl Cheng Kung Univ Hosp, Dept Pediat
Natl Cheng Kung Univ, Dept Med, Coll Med |
| 關鍵字: | Severe dengue
Sepsis
Bacteremia
Candidemia
Empirical therapy
Concurrent infection
Fatality |
| 日期: | 2019-04 |
| 上傳時間: | 2020-07-29 13:53:34 (UTC+8) |
| 出版者: | ELSEVIER TAIWAN |
| 摘要: | Background: Dengue is an important mosquito-borne tropical viral disease and dual infection, though rare, has been regarded as a risk factor for severe disease and mortality. However, few studies focused on bloodstream infections (BSIs) and empirical antibiotic therapy rarely addressed. Methods: Dengue patients with concurrent or subsequent BSIs between July 1 and December 31, 2015 were included. Clinical information, laboratory data, and drug susceptibility data were collected. Results: Totally 80 patients, with an in-hospital mortality rate of 32.5%, were included and categorized into three groups. 32 patients in Group I (BSI onset within 48 h after admission), 32 in Group II (between 48 h and one week), and 16 in Group III (more than one week). Patients in Group I were older (mean age: 75.6 vs. 72.6 or 69.6 years; P = 0.01) and had a higher Charlson comorbidity index (3.1 vs. 1.8 or 1.9; P = 0.02) than those in Group II or III. Streptococcus species (28.9%, 11/38) and Escherichia coli (23.7%, 9/38) were major pathogens in Group I. Enterobacteriaceae (38.2%, 13/34) isolates predominated in Group II. Fatal patients more often received inappropriate empirical antibiotic than the survivors (61.5% vs. 35.2%; P = 0.03). According to susceptibility data, pathogens in Group I and II shared similar susceptibility profiles, and levofloxacin, cefepime, or piperacillin/tazobactam, can be empirically prescribed for those hospitalized within one week. Conclusions: BSI pathogens vary among dengue patients. For adults with dengue and suspected BSI hospitalized within one week, empirical antimicrobial agents are recommended. Copyright (C) 2018, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. |
| 關聯: | Journal of Microbiology Immunology and Infection, v.52, n.2, pp.225-232 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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