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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32622

    標題: Ocimum sanctum Linn. as a natural source of skin anti-ageing compounds
    作者: Chaiyana, Wantida
    Anuchapreeda, Songyot
    Punyoyai, Chanun
    Neimkhum, Waranya
    Kuan-Han Lee(李冠漢)
    Wei-Chao Lin(林維炤)
    Shang-Chian Lue(呂尚謙)
    Viernstein, Helmut
    Mueller, Monika
    貢獻者: Chiang Mai Univ, Fac Pharm, Dept Pharmaceut Sci
    Chiang Mai Univ, Res Ctr Pharmaceut Nanotechnol
    Chiang Mai Univ, Fac Associated Med Sci, Dept Med Technol, Div Clin Microscopy
    Huachiew Chalermprakiet Univ, Fac Pharmaceut Sci, Dept Pharmaceut Technol
    Chia Nan Univ Pharm & Sci, Dept Pharm
    Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
    Chia Nan Univ Pharm & Sci, Inst Cosmet Sci
    Univ Vienna, Dept Pharmaceut Technol & Biopharmaceut
    關鍵字: Ocimum sanctum
    Rosmarinic acid
    Matrix metallopeptidase
    Nuclear factor kappa B
    日期: 2019-01
    上傳時間: 2020-07-29 13:52:31 (UTC+8)
    摘要: Ocimum sanctum Linn., widely used in food preparation, has been reported for several biological beneficial activities and thus potential for treatment of various health conditions. However, the biological activities related to skin anti-ageing, including anti-collagenase, anti-elastase, and anti-hyaluronidase activities, have not been reported so far. Therefore, this study aimed to investigate the skin anti-ageing activity of O. sanctum extracts. The aerial part of O. sanctum was extracted by fractionated extraction using n-hexane, ethyl acetate, and ethanol, respectively. Rosmarinic acid and total phenolic content was investigated. Antioxidant activity was determined by in vitro methods. Anti-inflammatory activity was investigated according to the inhibition of nuclear factor kappa B (NE-kappa B) expression and interleukin-6 (IL-6) secretion. The anti-ageing activity was investigated by in vitro inhibition of collagenase, elastase, and hyaluronidase activities. The ethanolic extract of O. sanctum., which had the highest yield (6.5%), contained the highest rosmarinic acid (19.3% w/w) and the highest total phenolic content (50.2 +/- 0.6 mg gallic acid/g sample). Additionally, it possessed the most potent antioxidant activity with the Trolox equivalent antioxidant capacity of 270.1 +/- 15.1 mu M/mg, equivalent concentration of 459.3 +/- 91.4 mu M/mg, and inhibition against 2, 2-diphenyl-1-picrylhydrazyl radical of 34.0 +/- 0.7%. The ethanolic extract also showed the highest anti-inflammatory activity with the inhibition against IL-6 secretion and NF-kappa B expression of 54.7 +/- 3.1% and 79.3 +/- 9.6%, respectively. Moreover, it also exerted the highest inhibition against matrix metallopeptidase-1 and hyaluronidase with the inhibition of 77.7 +/- 9.0% and 98.1 +/- 0.1%, respectively. Rosmarinic acid was found as the major compound responsible for those anti-ageing activities. Therefore, the ethanolic extract of O. sanctum is an attractive natural source of anti-skin ageing ingredient for further applications in cosmetic and/or cosmeceutical industry.
    關聯: Industrial Crops and Products, v.127, pp.217-224
    Appears in Collections:[藥學系(所)] 期刊論文
    [化妝品應用與管理系(所)] 期刊論文

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