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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/32613


    標題: PREDICTIVE EFFECT OF MALNUTRITION ON LONG-TERM CLINICAL OUTCOMES AMONG OLDER MEN: A PROSPECTIVELY OBSERVATIONAL COHORT STUDY
    作者: Ying-Hsin Hsu(徐盈欣)
    Chou, M-Y
    Chu, C-S
    Liao, M-C
    Wang, Y-C
    Lin, Y-T
    Chen, L-K
    Liang, C-K
    貢獻者: Kaohsiung Vet Gen Hosp, Ctr Geriatr & Gerontol
    Kaohsiung Vet Gen Hosp, Dept Internal Med, Div Neurol
    Chia Nan Univ Pharm & Sci,
    Natl Yang Ming Univ Taipei, Aging & Hlth Res Ctr
    Natl Yang Ming Univ, Sch Med, Dept Geriatr Med
    Kaohsiung Vet Gen Hosp, Dept Psychiat
    Taipei Vet Gen Hosp Taipei, Ctr Geriatr & Gerontol
    關鍵字: Malnutrition
    cognitive decline
    functional decline
    mortality
    older adults
    日期: 2019-11
    上傳時間: 2020-07-29 13:52:08 (UTC+8)
    出版者: SPRINGER FRANCE
    摘要: Objectives: To determine whether nutritional status can predict 3-year cognitive and functional decline, as well as 4-year all-cause mortality in older adults.DesignProspectively longitudinal cohort study. Setting and participants: The study recruited 354 men aged 65 years and older in the veteran's retirement community. Measures: Baseline nutritional status was evaluated using the Mini-Nutritional Assessment-Short Form (MNA-SF). Cognitive function and Activities of Daily Living (ADL) function were determined by the Mini-Mental State Examination (MMSE) and the Barthel Index, respectively. Three-year cognitive and functional decline were respectively defined as a >3 point decrease in the MMSE scores and lower ADL scores than at baseline. Univariate and multivariable logistic regression analyses were conducted to identify nutritional status as a risk factor in poor outcome. The Kaplan-Meier method and Cox proportional regression models were used to estimate the effect of malnutrition risk on the mortality. Results: According to MNS-SF, the prevalence of risk of malnutrition was 53.1% (188/354). Multivariate logistic regression found risk of malnutrition significantly associated with 3-year cognitive decline (Adjusted odds ratio [OR] 2.07, 95% Confidence Interval [CI] 1.05-4.08, P =0.036) and functional decline (Adjusted OR 1.83, 95% CI 1.01-3.34, P =0.047) compared with normal nutritional status. The hazard ratio (HR) for all-cause mortality was 1.8 times higher in residents at risk of malnutrition (Adjusted HR 1.82, 95% CI 1.19-2.79, P =0.006). Conclusions: Our results provide strong evidence that risk of malnutrition can predict not only cognitive and functional decline but also risk of all-cause mortality in older men living in a veteran retirement's community. Further longitudinal studies are needed to explore the causal relationship among nutrition, clinical outcomes, and the effect of an intervention for malnutrition.
    關聯: Journal of Nutrition Health & Aging, v.23, n.9, pp.876-882
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