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    题名: Risks of interstitial cystitis among patients with systemic lupus erythematosus: A population-based cohort study
    作者: Wen, Jen-Yu
    Lo, Tsia-Shu
    Chuang, Yao-Chi
    Chung-Han Ho(何宗翰)
    Long, Cheng-Yu
    Law, Kim-Seng
    Tong, Yat-Ching
    Wu, Ming-Ping
    贡献者: Chi Mei Med Ctr, Dept Obstet & Gynecol, Div Urogynecol
    Chang Gung Mem Hosp, Keelung Med Ctr, Dept Obstet & Gynecol
    Chang Gung Univ, Sch Med
    Chang Gung Univ, Coll Med, Kaohsiung Chang Gung Mem Hosp, Dept Urol
    Chi Mei Med Ctr, Dept Med Res
    Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
    Kaohsiung Med Univ, Coll Med, Grad Inst Med
    Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Dept Obstet & Gynecol
    Tungs Taichung MetroHarbor Hosp, Dept Obstet & Gynecol
    Natl Cheng Kung Univ Tainan, Natl Cheng Kung Univ Hosp, Coll Med, Dept Urol
    Fu Jen Catholic Univ, Coll Med, Dept Obstet & Gynecol
    关键词: interstitial cystitis
    bladder pain syndrome
    lupus cystitis
    systemic lupus erythematosus
    female
    日期: 2019-09
    上传时间: 2020-07-29 13:51:45 (UTC+8)
    出版者: WILEY
    摘要: Objective To investigate whether the risk of interstitial cystitis increases among the patients with systemic lupus erythematosus. Methods This was a nationwide population-based cohort study. Data were obtained from the National Health Insurance Research Database in Taiwan. Women aged >18 years newly diagnosed as systemic lupus erythematosus during 2001-2008 were identified as the control group. The comparison included individuals randomly selected from the National Health Insurance Research Database in the year of 2000, by matching one systemic lupus erythematosus participant with eight non-systemic lupus erythematosus participants with sex and age. These participants were followed up until being diagnosed as interstitial cystitis, or the end of 2011. Women diagnosed with lupus cystitis were excluded from this study. Results This study included 7240 women with systemic lupus erythematosus and 57 920 women without systemic lupus erythematosus as controls. The incidence rate of interstitial cystitis was significantly higher in the systemic lupus erythematosus group, with an incidence rate ratio of 2.26 (95% confidence interval 1.57-3.27, P < 0.0001). After adjustment, the risk increased by 2.45-fold (adjusted hazard ratio 2.45, 95% confidence interval 1.57-3.27, P < 0.05). Age as a factor increases incidence rate ratios among all age groups, 2.12-, 3.32- and 4.65-fold. Age >= 45 years had an increased adjusted hazard ratio (2.07, 95% confidence interval 1.37-3.13, P < 0.05). Comorbidities, for example, hypertension, diabetes mellitus, dyslipidemia and renal disease, were insignificant. Conclusions This is the first population-based cohort study showing a higher incidence of interstitial cystitis among patients with systemic lupus erythematosus. These findings support the concordance of interstitial cystitis with autoimmune diseases, and the temporal relationship to develop interstitial cystitis in patients with systemic lupus erythematosus.
    關聯: International Journal of Urology, v.26, n.9, pp.897-902
    显示于类别:[Dept. of Hospital and Health (including master's program)] Periodical Articles

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