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| 標題: | Risks of interstitial cystitis among patients with systemic lupus erythematosus: A population-based cohort study |
| 作者: | Wen, Jen-Yu
Lo, Tsia-Shu
Chuang, Yao-Chi
Chung-Han Ho(何宗翰)
Long, Cheng-Yu
Law, Kim-Seng
Tong, Yat-Ching
Wu, Ming-Ping |
| 貢獻者: | Chi Mei Med Ctr, Dept Obstet & Gynecol, Div Urogynecol
Chang Gung Mem Hosp, Keelung Med Ctr, Dept Obstet & Gynecol
Chang Gung Univ, Sch Med
Chang Gung Univ, Coll Med, Kaohsiung Chang Gung Mem Hosp, Dept Urol
Chi Mei Med Ctr, Dept Med Res
Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
Kaohsiung Med Univ, Coll Med, Grad Inst Med
Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Dept Obstet & Gynecol
Tungs Taichung MetroHarbor Hosp, Dept Obstet & Gynecol
Natl Cheng Kung Univ Tainan, Natl Cheng Kung Univ Hosp, Coll Med, Dept Urol
Fu Jen Catholic Univ, Coll Med, Dept Obstet & Gynecol |
| 關鍵字: | interstitial cystitis
bladder pain syndrome
lupus cystitis
systemic lupus erythematosus
female |
| 日期: | 2019-09 |
| 上傳時間: | 2020-07-29 13:51:45 (UTC+8) |
| 出版者: | WILEY |
| 摘要: | Objective To investigate whether the risk of interstitial cystitis increases among the patients with systemic lupus erythematosus. Methods This was a nationwide population-based cohort study. Data were obtained from the National Health Insurance Research Database in Taiwan. Women aged >18 years newly diagnosed as systemic lupus erythematosus during 2001-2008 were identified as the control group. The comparison included individuals randomly selected from the National Health Insurance Research Database in the year of 2000, by matching one systemic lupus erythematosus participant with eight non-systemic lupus erythematosus participants with sex and age. These participants were followed up until being diagnosed as interstitial cystitis, or the end of 2011. Women diagnosed with lupus cystitis were excluded from this study. Results This study included 7240 women with systemic lupus erythematosus and 57 920 women without systemic lupus erythematosus as controls. The incidence rate of interstitial cystitis was significantly higher in the systemic lupus erythematosus group, with an incidence rate ratio of 2.26 (95% confidence interval 1.57-3.27, P < 0.0001). After adjustment, the risk increased by 2.45-fold (adjusted hazard ratio 2.45, 95% confidence interval 1.57-3.27, P < 0.05). Age as a factor increases incidence rate ratios among all age groups, 2.12-, 3.32- and 4.65-fold. Age >= 45 years had an increased adjusted hazard ratio (2.07, 95% confidence interval 1.37-3.13, P < 0.05). Comorbidities, for example, hypertension, diabetes mellitus, dyslipidemia and renal disease, were insignificant. Conclusions This is the first population-based cohort study showing a higher incidence of interstitial cystitis among patients with systemic lupus erythematosus. These findings support the concordance of interstitial cystitis with autoimmune diseases, and the temporal relationship to develop interstitial cystitis in patients with systemic lupus erythematosus. |
| 關聯: | International Journal of Urology, v.26, n.9, pp.897-902 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
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