Hypovitaminosis D in Postherpetic Neuralgia-High Prevalence and Inverse Association with Pain: A Retrospective Study

doi:10.3390/nu11112787

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標題:	Hypovitaminosis D in Postherpetic Neuralgia-High Prevalence and Inverse Association with Pain: A Retrospective Study
作者:	Jen-Yin Chen(陳貞吟) Lin, Yao-Tsung Wang, Li-Kai Hung, Kuo-Chuan Lan, Kuo-Mao Ho, Chung-Han Chang, Chia-Yu
貢獻者:	Chi Mei Med Ctr, Dept Anesthesiol Chia Nan Univ Pharm & Sci, Dept Senior Citizen Serv Management Chi Mei Med Ctr, Dept Med Res Chi Mei Med Ctr, Dept Neurol Southern Taiwan Univ Sci & Technol, Ctr Gen Educ
關鍵字:	hypovitaminosis D 25-hydroxyvitamin D postherpetic neuralgia spontaneous pain brush-evoked pain varicella-zoster virus immunoglobulin DN4questionnaire
日期:	2019-11
上傳時間:	2020-07-29 13:51:39 (UTC+8)
出版者:	MDPI
摘要:	Hypovitaminosis D (25-hydroxyvitamin D (25(OH)D) <75 nmol/L) is associated with neuropathic pain and varicella-zoster virus (VZV) immunity. A two-part retrospective hospital-based study was conducted. Part I (a case-control study): To investigate the prevalence and risk of hypovitaminosis D in postherpetic neuralgia (PHN) patients compared to those in gender/index-month/age-auto matched controls who underwent health examinations. Patients aged >= 50 years were automatically selected by ICD-9 codes for shingle/PHN. Charts were reviewed. Part II (a cross-sectional study): To determine associations between 25(OH)D, VZV IgG/M, pain and items in the DN4 questionnaire at the first pain clinic visit of patients. Independent predictors of PHN were presented as adjusted odds ratios(AOR) and 95% confidence intervals (CI). Prevalence (73.9%) of hypovitaminosis D in 88 patients was high. In conditional logistic regressions, independent predictors for PHN were hypovitaminosis D (AOR3.12, 95% CI1.73-5.61), malignancy (AOR3.21, 95% CI 1.38-7.48) and Helicobacter pylori-related peptic ulcer disease (AOR3.47, 95% CI 1.71-7.03). 25(OH)D was inversely correlated to spontaneous/brush-evoked pain. Spontaneous pain was positively correlated to VZV IgM. Based on the receiver operator characteristic curve, cutoffs for 25(OH)D to predict spontaneous and brush-evoked pain were 67.0 and 169.0 nmol/L, respectively. A prospective, longitudinal study is needed to elucidate the findings.
關聯:	Nutrients, v.11, n.11, 2787
顯示於類別:	[高齡福祉養生管理系] 期刊論文

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