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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32602

    標題: Hypovitaminosis D in Postherpetic Neuralgia-High Prevalence and Inverse Association with Pain: A Retrospective Study
    作者: Jen-Yin Chen(陳貞吟)
    Lin, Yao-Tsung
    Wang, Li-Kai
    Hung, Kuo-Chuan
    Lan, Kuo-Mao
    Ho, Chung-Han
    Chang, Chia-Yu
    貢獻者: Chi Mei Med Ctr, Dept Anesthesiol
    Chia Nan Univ Pharm & Sci, Dept Senior Citizen Serv Management
    Chi Mei Med Ctr, Dept Med Res
    Chi Mei Med Ctr, Dept Neurol
    Southern Taiwan Univ Sci & Technol, Ctr Gen Educ
    關鍵字: hypovitaminosis D
    25-hydroxyvitamin D
    postherpetic neuralgia
    spontaneous pain
    brush-evoked pain
    varicella-zoster virus immunoglobulin
    日期: 2019-11
    上傳時間: 2020-07-29 13:51:39 (UTC+8)
    出版者: MDPI
    摘要: Hypovitaminosis D (25-hydroxyvitamin D (25(OH)D) <75 nmol/L) is associated with neuropathic pain and varicella-zoster virus (VZV) immunity. A two-part retrospective hospital-based study was conducted. Part I (a case-control study): To investigate the prevalence and risk of hypovitaminosis D in postherpetic neuralgia (PHN) patients compared to those in gender/index-month/age-auto matched controls who underwent health examinations. Patients aged >= 50 years were automatically selected by ICD-9 codes for shingle/PHN. Charts were reviewed. Part II (a cross-sectional study): To determine associations between 25(OH)D, VZV IgG/M, pain and items in the DN4 questionnaire at the first pain clinic visit of patients. Independent predictors of PHN were presented as adjusted odds ratios(AOR) and 95% confidence intervals (CI). Prevalence (73.9%) of hypovitaminosis D in 88 patients was high. In conditional logistic regressions, independent predictors for PHN were hypovitaminosis D (AOR3.12, 95% CI1.73-5.61), malignancy (AOR3.21, 95% CI 1.38-7.48) and Helicobacter pylori-related peptic ulcer disease (AOR3.47, 95% CI 1.71-7.03). 25(OH)D was inversely correlated to spontaneous/brush-evoked pain. Spontaneous pain was positively correlated to VZV IgM. Based on the receiver operator characteristic curve, cutoffs for 25(OH)D to predict spontaneous and brush-evoked pain were 67.0 and 169.0 nmol/L, respectively. A prospective, longitudinal study is needed to elucidate the findings.
    關聯: Nutrients, v.11, n.11, 2787
    Appears in Collections:[老人服務事業管理系] 期刊論文

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