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    標題: A New Histone Deacetylase Inhibitor Enhances Radiation Sensitivity through the Induction of Misfolded Protein Aggregation and Autophagy in Triple-Negative Breast Cancer
    作者: Chiu, Hui-Wen
    Yeh, Ya-Ling
    Ho, Sheng-Yow
    Wu, Yuan-Hua
    Bour-Jr Wang(王伯智)
    Huang, Wei-Jan
    Ho, Yuan-Soon
    Wang, Ying-Jan
    Chen, Li-Ching
    Tu, Shih-Hsin
    貢獻者: Taipei Med Univ, Coll Med, Grad Inst Clin Med
    Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Nephrol
    Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth
    Chi Mei Med Ctr, Dept Radiat Oncol
    Chang Jung Christian Univ, Grad Inst Med Sci
    Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Radiat Oncol
    Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med
    Chia Nan Univ Pharm & Sci, Inst Cosmet Sci
    Taipei Med Univ, Grad Inst Pharmacognosy
    Taipei Med Univ, TMU Res Ctr Canc Translat Med
    Taipei Med Univ, Coll Med, Grad Inst Med Sci
    Taipei Med Univ Hosp, Dept Lab Med
    Taipei Med Univ, Coll Med Sci & Technol, Sch Med Lab Sci & Biotechnol
    Taipei Med Univ Hosp, Dept Surg, Div Breast Surg
    Taipei Med Univ, Taipei Canc Ctr
    Taipei Med Univ, Coll Med, Sch Med, Dept Surg
    關鍵字: histone deacetylase inhibitor
    aggresome
    radiation
    autophagy
    triple-negative breast cancer
    日期: 2019
    上傳時間: 2020-07-29 13:51:29 (UTC+8)
    出版者: MDPI
    摘要: Radiation therapy (RT) is one of the main treatments for triple-negative breast cancer (TNBC). However, many patients experience RT failure due to the metastatic potential of RT and the radiation resistance of several cancers. Histone deacetylase inhibitors (HDACis) can serve as radiosensitizers. In this study, we investigated whether a novel HDACi, TMU-35435, could reinforce radiosensitivity through the induction of misfolded protein aggregation and autophagy in TNBC. Significantly enhanced toxicity was found for the combination treatment compared with TMU-35435 or irradiation (IR) treatment alone in TNBC cells. The combination treatment induced misfolded protein aggregation and TMU-35435 inhibited the interaction of HDAC6 with dynein. Furthermore, the combined treatment induced endoplasmic reticulum (ER) stress but did not trigger apoptosis. In addition, the combination treatment caused autophagic cell death. Tumor growth in the mouse of model orthotopic breast cancer was suppressed by the combination treatment through the induction of ER stress and autophagy. These findings support the future evaluation of the novel HDACi TMU-35435, as a potent radiosensitizer in TNBC.
    關聯: Cancers, v.11, n.11, 1703
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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