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| 標題: | High exposure to statins decrease the risk of new-onset dementia A nationwide population-based longitudinal cohort study |
| 作者: | Chang, Chih-Feng
Liou, Yi-Sheng
Lin, Tsung-Kun
Ma, Stacey
Hu, Yu-Ru
Chen, Hung-Yi
Jong, Gwo-Ping |
| 貢獻者: | Armed Force Taichung Gen Hosp, Div Cardiol, Dept Internal Med
Natl Def Med Ctr
Taichung Vet Gen Hosp, Dept Family Med
Natl Def Med Ctr, Sch Publ Hlth
Med Affairs Bur, Armed Forces Med Supplies Off
Univ Calif San Diego, La Jolla
Chia Nan Univ Pharm & Sci, Div Nutr
China Med Univ, Inst Pharm
Chung Shan Med Univ Hosp, Div Internal Cardiol
Chung Shan Med Univ, 110,Sect 1,Chien Kuo N Rd |
| 關鍵字: | high exposure to statins
hyperlipidemia
new-onset dementia |
| 日期: | 2019-08 |
| 上傳時間: | 2020-07-29 13:51:27 (UTC+8) |
| 出版者: | LIPPINCOTT WILLIAMS & WILKINS |
| 摘要: | Several studies have shown that statin users have a lower risk of new-onset dementia (NOD) compared nonusers. However, other studies have shown opposite results. In this study, we investigated the association between the use of statins and the development of NOD. This was a longitudinal cohort study using data from claim forms submitted to the Taiwanese Bureau of National Health Insurance. The study included patients with NOD and non-NOD subjects from January 2002 to December 2013. We estimated the hazard ratios (HRs) of NOD associated with statin use, whereas nonuser subjects were used as a reference group. A total of 19,522 NOD cases were identified in 100,610 hyperlipidemic patients during the study period. The risk of NOD, after adjusting for sex, age, comorbidities, and concurrent medication, was lower among statin users than nonusers (HR 0.95, 95% CI [ confidence interval] 0.94-0.96; P<. 001). The adjusted HRs for NOD were 1.53 (95% CI, 1.45-1.62), 0.63 (95% CI, 0.57-0.71), and 0.34 (95% CI, 0.30-0.38) when the cumulative defined daily doses ranged from 28 to 365, 366 to 730, and more than 730 relative to nonusers, respectively. Weconcluded that statin use is associated with a decreasedNODrisk. The protective effect of statins forNODseemedto be related to high exposure to statins. This study also highlights that high exposure to statins has a dose-response effect on lowering NOD risk. |
| 關聯: | Medicine, v.98, n.34, e16931 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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