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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32596

    標題: Significant effects of late evening snack on liver functions in patients with liver cirrhosis: A meta-analysis of randomized controlled trials
    作者: Chen, Chen-Ju
    Wang, Liang-Chao
    Hsing-Tao Kuo(郭行道)
    Fang, Yu-Chiung
    Lee, Huan-Fang
    貢獻者: Natl Cheng Kung Univ Hosp, Coll Med, Dept Nursing
    Natl Cheng Kung Univ Hosp, Coll Med, Dept Surg, Div Neurosurg
    Natl Cheng Kung Univ, Coll Med, Dept Nursing
    Chi Mei Med Ctr, Dept Internal Med, Div Hepatogastroenterol
    Chia Nan Univ Pharm & Sci, Dept Senior Citizen Serv Management
    關鍵字: hepatocellular carcinoma
    late evening snack
    liver cirrhosis
    日期: 2019-07
    上傳時間: 2020-07-29 13:51:22 (UTC+8)
    出版者: WILEY
    摘要: Background and Aim Reducing post-absorptive (fasting) phase by eating late evening snacks (LESs) is a potential intervention to improve substrate utilization and reverse sarcopenia. This study analyzed the results of published randomized controlled trials and controlled clinical trials to evaluate the effects of LES on liver function of patients with cirrhosis. Methods A meta-analysis was conducted. The search strategy included electronic database searches, and 300 articles were searched. Eight of these articles provided qualified data for pooling and analysis. Outcomes assessments included serum albumin, total bilirubin, alanine aminotransferase, prothrombin time, and aspartate aminotransferase, complications of cirrhosis, severity of liver disease, and blood glucose levels. Results Our analysis included eight studies comprising 341 patients (167 in LES groups and 174 in control groups). The results showed that LES intervention helped to maintain liver reserves. These eight studies demonstrated that LES intervention had significant effects for liver biochemical parameters on albumin, ammonia, and prothrombin time, with respective effect sizes of 0.233, -0.425, and -0.589; liver enzymes include aspartate aminotransferase and alanine aminotransferase, with respective effect sizes of -0.320 and -0.284. Studies on clinical signs of liver dysfunction showed lower occurrence rates of ascites and hepatic encephalopathy than in the control group. LES had no significant effect on Child-Pugh score. Conclusions The overall results of the meta-analysis indicated that having LES can improve liver function reserve for patients with liver cirrhosis, with or without hepatocellular carcinoma. LES is a promising intervention for reversing anabolic resistance and the sarcopenia of cirrhosis, resulting in an improved quality of life for patients with cirrhosis.
    關聯: Journal of Gastroenterology and Hepatology, v.34, n.7, pp.1143-1152
    Appears in Collections:[老人服務事業管理系] 期刊論文

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