Clinicopathologic and Prognostic Significance of Thymopoietin-alpha Overexpression in Gastric Cancer

doi:10.7150/jca.30738

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Title:	Clinicopathologic and Prognostic Significance of Thymopoietin-alpha Overexpression in Gastric Cancer
Authors:	Ding-Ping Sun(孫定平) Liew, Phui-Ly Lin, Chih-Chan Hung, Shih-Ting Chen, Tai-Chi Fang, Chia-Lang Kai-Yuan Lin(林凱元)
Contributors:	Chi Mei Med Ctr, Dept Surg Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol Taipei Med Univ, Shuang Ho Hosp, Dept Pathol Taipei Med Univ, Coll Med, Dept Pathol Chi Mei Med Ctr, Dept Med Res Taipei Med Univ, Wang Fang Hosp, Dept Pathol Chia Nan Univ Pharm & Sci, Dept Biotechnol
Keywords:	gastric cancer TMPO-alpha prognosis
Date:	2019
Issue Date:	2020-07-29 13:51:06 (UTC+8)
Publisher:	IVYSPRING INT PUBL
Abstract:	As one of the deadliest and most common malignancies in the world, gastric cancer (GC) represents a serious health threat. Despite recent advances in the field, the prognosis of patients with metastatic GC remains poor. In this study, we aimed to investigate the clinical impact of the alpha subunit of the nuclear structural protein thymopoietin (TMPO-alpha) in GC. The expression of TMPO-alpha in seven gastric cell lines was detected by immunoblotting. The expression level of TMPO-alpha levels in gastric tissues collected from 145 GC patients was examined by immunohistochemistry. The correlations between TMPO-alpha expression level and clinicopathologic parameters, as well as the association of TMPO-alpha expression with overall survival, were assessed. Immunohistochemistry showed that the expression of TMPO-alpha was significantly higher in GC tissues and cells in comparison with non-tumor tissues and cells. Furthermore, the overexpression of TMPO-alpha in gastric tissues (56%) was positively associated with Lauren classification (P = 0.0159), nodal status (P = 0.0265), distant metastasis (P < 0.0001), stage (P = 0.0367), and degree of differentiation (P = 0.0009). Patients with high TMPO-alpha levels had a significantly poorer overall survival than those with low levels (P = 0.001). Multivariate Cox regression analysis also indicated that TMPO-alpha was an independent prognostic marker for GC (P = 0.045). In addition, studies conducted in GC cells indicated that knockdown of TMPO-alpha suppressed cell proliferation and invasion. These findings indicate that TMPO-alpha overexpression can predict clinicopathologic features and the outcome of patients with GC.
Relation:	Journal of Cancer, v.10, n.21, pp.5099-5107
Appears in Collections:	[Dept. of Biotechnology (including master's program)] Periodical Articles [Dept. of Food Science & Technology] Periodical Articles

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