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| 標題: | Role of gait speed and grip strength in predicting 10-year cognitive decline among community-dwelling older people |
| 作者: | Ming-Yueh Chou(周明岳)
Nishita, Yukiko
Nakagawa, Takeshi
Tange, Chikako
Tomida, Makiko
Shimokata, Hiroshi
Otsuka, Rei
Chen, Liang-Kung
Arai, Hidenori |
| 貢獻者: | Kaohsiung Vet Gen Hosp, Ctr Geriatr & Gerontol
Natl Yang Ming Univ, Aging & Hlth Res Ctr
Natl Yang Ming Univ, Sch Med, Dept Geriatr Med
Natl Ctr Geriatr & Gerontol
Chia Nan Univ Pharm & Sci
Natl Ctr Geriatr & Gerontol, Dept Epidemiol Aging
Natl Ctr Geriatr & Gerontol, Ctr Gerontol & Social Sci
Japan Soc Promot Sci, Chiyoda Ku
Nagoya Univ Arts & Sci, Grad Sch Nutrit Sci, Chikusa Ku, Furo Cho
Taipei Vet Gen Hosp, Ctr Geriatr & Gerontol |
| 關鍵字: | Gait speed
Handgrip strength
Cognition
MMSE
DSST |
| 日期: | 2019-06 |
| 上傳時間: | 2020-07-29 13:51:00 (UTC+8) |
| 出版者: | BMC |
| 摘要: | BackgroundThe gait speed and handgrip strength represented the core determinants of physical frailty and sarcopenia, which were reported to be associated with cognitive impairment and decline. Different physical measures might differentially affect cognitive changes, such as higher-level cognitive change and global cognitive decline. This study examined the differential associations of gait speed and handgrip strength with 10-year cognitive changes among community-dwelling older people.MethodsParticipants aged 60years and over living in the community were invited for study. Gait speed and handgrip strength were classified into 5 groups based on quintiles at baseline. Cognitive functions were assessed using the Mini-Mental State Examination (MMSE) and Digit Symbol Substitution Test (DSST) every 2 years from baseline for a period of 10years. Linear mixed effects models were used to determine the role of gait speed and handgrip strength in the prediction of 10-year cognitive changes by adjusting covariates, including age, gender, education, depressive symptoms, marital status, smoking status, instrumental activities of daily life (IADL), Charlson Comorbidity Index (CCI), and body mass index (BMI) at baseline.ResultsA total of 1096 participants were enrolled in the study. The mean age was 69.45.8years and 50.9% were male. The slowest gait speed group showed a significantly greater decline in the DSST scores over 10years than the highest group (estimate=0.28 and P=0.003), but not in the MMSE scores (estimate=0.05 and P=0.078). The lowest handgrip strength group showed a significantly greater decline in the MMSE scores than the highest group (estimate=0.06 and P=0.039) and in the DSST scores than the highest two quintiles (estimate=0.20 and P=0.033 for the fourth quintile; estimate=0.20 and P=0.040 for the highest quintile) over 10-year follow-up.Conclusions A slow gait speed could predict 10-year cognitive decline using DSST, and a low handgrip strength could predict 10-year cognitive decline using MMSE in addition to DSST. Thus both physical measures are lined to cognitive decline but there may be different mechanisms between brain and physical functions. |
| 關聯: | Bmc Geriatrics, v.19, 186 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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