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| 標題: | Renal Cell Carcinoma Antigen Expression in Primary Cutaneous Endocrine Mucinous Carcinomas: A Case Series of 14 Patients and Review of the Literature |
| 作者: | Ansari, Ahmed N.
Bobos, Mattheos
Shih, Shawn
Mark Chien-Chin Chen(陳建欽)
Ardakani, Nima M.
Rosales, Cecilia M.
Chen, Chih-Jung
Savage, Christopher
Bracey, Tim
McKee, Phillip H.
Cerruto, Carlos A. |
| 貢獻者: | Univ Cent Florida, Coll Med, Orlando
Microdiagnostics Ltd
Hellen Fdn Canc Res, Mol Oncol Lab
Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Pathol
QEII Med Ctr, PathWest Lab Med, Nedlands
SEPA Labs, Southeastern Pathol Associates
Changhua Christian Hosp, Dept Surg Pathol
Chung Shan Med Univ, Sch Med
Mid Florida Dermatol & Plast Surg
Royal Cornwall Hosp, Truro
Plymouth Hosp NHS Trust, Plymouth
Brigham & Womens Hosp, Dept Surg Pathol
Mid Florida Pathol |
| 關鍵字: | endocrine mucin-producing sweat gland carcinoma
primary cutaneous mucinous carcinoma
renal cell carcinoma antigen
review
case series |
| 日期: | 2019-08 |
| 上傳時間: | 2020-07-29 13:50:23 (UTC+8) |
| 出版者: | LIPPINCOTT WILLIAMS & WILKINS |
| 摘要: | Endocrine mucin-producing sweat gland carcinoma (EMPSGC) and primary cutaneous mucinous carcinoma (PCMC) are both uncommon low-grade cutaneous adnexal tumors with predilection for the eyelids of elderly women. Their clinical appearance is nonspecific, typically presenting as a slowly growing poorly circumscribed papule, nodule, plaque, or swelling. Histological features of EMPSGC include a lobulated dermal neoplasm with bland cytology and an invasive mucinous component in up to half of the cases. PCMC exhibits tumor nests suspended in abundant pools of mucin with focal strands or nests of tumor cells infiltrating the dermis. Because of their rarity and banal cytological features, both entities pose a risk for misdiagnosis with other benign/malignant cutaneous adnexal neoplasms. Histomorphological features can suggest a diagnosis of EMPSGC or PCMC, but immunohistochemistry is necessary for confirmation. A review of the literature showed variable results of antigens present in EMPSGC, and many of the positive markers only show sparse or focal immunoreactivity of tumor cells. As a result, diffusely positive markers play a crucial role in identification of these tumors, particularly with initial superficial biopsies. We present 9 cases of EMPSGC and 5 cases of PCMC with strong and diffuse immunoreactivity to renal cell carcinoma antigen. This novel finding can be useful in the diagnosis of EMPSGC and PCMC in combination with other known positive markers to differentiate them from other cutaneous neoplasms. In addition, it provides further evidence that EMPSGC could be a precursor lesion to PCMC with both existing on a spectrum. |
| 關聯: | American Journal of Dermatopathology, v.41, n.8, pp.571-577 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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