Correlation between kidney transplantation and colorectal cancer in hemodialysis patients: A nationwide, retrospective, population-based cohort study

doi:10.1186/s12885-019-6283-z

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 保健營養系(所) > 期刊論文 > Item 310902800/32557

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標題:	Correlation between kidney transplantation and colorectal cancer in hemodialysis patients: A nationwide, retrospective, population-based cohort study
作者:	Wang, Han-En Liao, Yu-Chan Hu, Je-Ming Wu, Wen-Chih Chou, Wan-Yun Chen, Yong-Chen Chou, Yu-Ching Hung, Chi-Feng Yu-Feng Tian(田宇峯) You, San-Lin Sun, Chien-An
貢獻者:	Triserv Gen Hosp, Natl Def Med Ctr, Dept Med, Div Nephrol Natl Def Med Ctr, Sch Publ Hlth Natl Def Med Ctr, Grad Inst Med Sci Triserv Gen Hosp, Natl Def Med Ctr, Dept Surg, Div Colorectal Surg Taipei Vet Gen Hosp, Suao & Yuanshan Branches, Dept Surg Natl Def Med Ctr, Grad Inst Life Sci Fu Jen Catholic Univ, Coll Med, Dept Med Fu Jen Catholic Univ, Coll Med, Big Data Res Ctr Chi Mei Med Ctr, Dept Surg, Div Colorectal Surg Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Fu Jen Catholic Univ, Coll Med, Dept Publ Hlth
關鍵字:	Colorectal cancer Hemodialysis Kidney transplantation Retrospective cohort study
日期:	2019
上傳時間:	2020-07-29 13:49:48 (UTC+8)
出版者:	BMC
摘要:	Background Kidney transplantation (KT) correlates with an increased risk of developing several malignancies; however, the risk of colorectal cancer (CRC) after KT remains debatable and has been marginally explored. Hence, in this nationwide, retrospective, population-based cohort study, we aimed to examine the correlation between KT and CRC in a large-scale population-based Chinese cohort. Methods We identified a total of 3739 regular hemodialysis patients undergoing KT (exposed cohort) and 42,324 hemodialysis patients not undergoing KT (non-exposed cohort) between 2000 and 2008 from Taiwan's National Health Insurance Research Database (NHIRD). Both cohorts were followed up from January 1, 2000, to the date of CRC diagnosis, death, or the end of 2013. Using Kaplan-Meier method, we measured the cumulative incidence of CRC in each cohort. Furthermore, Cox proportional hazards models were used to compute hazards ratios (HRs) and 95% confidence intervals (CIs) to estimate the correlation between KT and CRC in hemodialysis patients. Results The Kaplan-Meier analysis revealed that the cumulative incidence of CRC was significantly higher in the exposed cohort than in the non-exposed cohort (log-rank test, P < 0.001). After adjusting for potential confounders, the exposed cohort exhibited a significantly increased risk of CRC compared with the non-exposed cohort (adjusted HR, 1.34; 95% CI, 1.11-1.62). Conclusions Hemodialysis patients undergoing KT have a significantly higher risk of CRC than those not undergoing KT. Cancer should continue to be a primary focus of prevention during KT.
關聯:	Bmc Cancer, v.19, n.1, pp.1120
顯示於類別:	[保健營養系(所) ] 期刊論文

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