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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32557

    標題: Correlation between kidney transplantation and colorectal cancer in hemodialysis patients: A nationwide, retrospective, population-based cohort study
    作者: Wang, Han-En
    Liao, Yu-Chan
    Hu, Je-Ming
    Wu, Wen-Chih
    Chou, Wan-Yun
    Chen, Yong-Chen
    Chou, Yu-Ching
    Hung, Chi-Feng
    Yu-Feng Tian(田宇峯)
    You, San-Lin
    Sun, Chien-An
    貢獻者: Triserv Gen Hosp, Natl Def Med Ctr, Dept Med, Div Nephrol
    Natl Def Med Ctr, Sch Publ Hlth
    Natl Def Med Ctr, Grad Inst Med Sci
    Triserv Gen Hosp, Natl Def Med Ctr, Dept Surg, Div Colorectal Surg
    Taipei Vet Gen Hosp, Suao & Yuanshan Branches, Dept Surg
    Natl Def Med Ctr, Grad Inst Life Sci
    Fu Jen Catholic Univ, Coll Med, Dept Med
    Fu Jen Catholic Univ, Coll Med, Big Data Res Ctr
    Chi Mei Med Ctr, Dept Surg, Div Colorectal Surg
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Fu Jen Catholic Univ, Coll Med, Dept Publ Hlth
    關鍵字: Colorectal cancer
    Kidney transplantation
    Retrospective cohort study
    日期: 2019
    上傳時間: 2020-07-29 13:49:48 (UTC+8)
    出版者: BMC
    摘要: Background Kidney transplantation (KT) correlates with an increased risk of developing several malignancies; however, the risk of colorectal cancer (CRC) after KT remains debatable and has been marginally explored. Hence, in this nationwide, retrospective, population-based cohort study, we aimed to examine the correlation between KT and CRC in a large-scale population-based Chinese cohort. Methods We identified a total of 3739 regular hemodialysis patients undergoing KT (exposed cohort) and 42,324 hemodialysis patients not undergoing KT (non-exposed cohort) between 2000 and 2008 from Taiwan's National Health Insurance Research Database (NHIRD). Both cohorts were followed up from January 1, 2000, to the date of CRC diagnosis, death, or the end of 2013. Using Kaplan-Meier method, we measured the cumulative incidence of CRC in each cohort. Furthermore, Cox proportional hazards models were used to compute hazards ratios (HRs) and 95% confidence intervals (CIs) to estimate the correlation between KT and CRC in hemodialysis patients. Results The Kaplan-Meier analysis revealed that the cumulative incidence of CRC was significantly higher in the exposed cohort than in the non-exposed cohort (log-rank test, P < 0.001). After adjusting for potential confounders, the exposed cohort exhibited a significantly increased risk of CRC compared with the non-exposed cohort (adjusted HR, 1.34; 95% CI, 1.11-1.62). Conclusions Hemodialysis patients undergoing KT have a significantly higher risk of CRC than those not undergoing KT. Cancer should continue to be a primary focus of prevention during KT.
    關聯: Bmc Cancer, v.19, n.1, pp.1120
    Appears in Collections:[保健營養系(所) ] 期刊論文

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