Association between abdominal hernia and the risk of subsequent dementia

doi:10.1002/brb3.1434

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Title:	Association between abdominal hernia and the risk of subsequent dementia
Authors:	Hung, Kuo-Chuan Sun, Cheuk-Kwan Jen-Yin Chen(陳貞吟) Wang, Hsiang-Chi Kao, Chia-Hung
Contributors:	Chi Mei Med Ctr, Dept Anesthesiol I Shou Univ, E Da Hosp, Sch Med Int Students, Dept Emergency Med Chia Nan Univ Pharm & Sci, Dept Senior Citizen Serv Management China Med Univ Hosp, Management Off Hlth Data China Med Univ, Coll Med China Med Univ, Coll Med, Grad Inst Biomed Sci China Med Univ Hosp, Ctr Augmented Intelligence Healthcare, Dept Nucl Med China Med Univ Hosp, Ctr Augmented Intelligence Healthcare, PET Ctr Asia Univ, Dept Bioinformat & Med Engn
Keywords:	cohort study dementia hernia matrix metalloproteinases
Date:	2019-11
Issue Date:	2020-07-29 13:49:40 (UTC+8)
Publisher:	WILEY
Abstract:	Objective Matrix metalloproteinases (MMPs) may play a role in the pathophysiology of neurodegenerative disease and hernia formation. This retrospective cohort study was designed to assess whether there is an association between hernia and the risk of dementia. Materials and Methods Patients (>= 45 years) with hernias were identified between 2000 and 2008 from a longitudinal claims data of one million beneficiaries from Taiwan's National Health Insurance program. A control group of patients with comparable distributions of sex, age, socioeconomic status, urbanization, and medical comorbidities without hernia were chosen for matching in a ratio of 1:1. Patients previously diagnosed with dementia were excluded. Follow-up ended on December 31, 2013. Incidence rate of dementia was compared between patients with hernias and those without. Cox proportional hazards models were used to estimate hazards relative to those of the control group. Results After matching, there were 4,784 hernia and 4,784 nonhernia patients. Hernia patients showed a higher incidence rate and hazard ratio of dementia than those in nonhernia group (8.82 vs. 7.19/1,000 person-years; adjusted hazard ratio [aHR], 1.24; 95% CI, 1.07 to 1.45; p < .01). Advanced age (p < .0001), hypertension (p = .0139), head injury (p = .0003), and stroke (p = .041) were found to be risk factors for dementia, while patients with high socioeconomic status (p < .01) and history of coronary artery disease (p = .0292) were unlikely to develop dementia in our cohort study. Conclusion Patients with hernias were associated with a higher incidence of dementia than those without. Our finding should be validated in further prospective studies with larger samples.
Relation:	Brain and Behavior, v.9, n.11, e01434
Appears in Collections:	[Dept. of Senior Service and Health Management] Periodical Articles

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