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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32536

    標題: Gamma knife radiosurgery for the treatment of cavernous sinus meningiomas: post-treatment long-term clinical outcomes, complications, and volume changes
    作者: Yi-Chieh Hung(洪翊傑)
    Lee, Cheng-Chia
    Guo, Wan-Yuo
    Shiau, Cheng-Ying
    Chang, Yue-Cune
    Pan, David Hung-Chi
    Sheehan, Jason P.
    Chung, Wen-Yuh
    貢獻者: Chi Mei Med Ctr, Dept Neurosurg
    Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
    Univ Virginia Hlth Syst, Dept Neurosurg
    Taipei Vet Gen Hosp, Neurol Inst, Dept Neurosurg
    Natl Yang Ming Univ, Sch Med
    Taipei Vet Gen Hosp, Dept Radiol
    Taipei Vet Gen Hosp, Canc Ctr
    Tamkang Univ, Dept Math
    Taipei Med Univ, Shuang Ho Hosp, Dept Neurosurg
    關鍵字: Cavernous sinus
    Prognostic factor
    日期: 2019-06
    上傳時間: 2020-07-29 13:48:55 (UTC+8)
    出版者: SPRINGER
    摘要: PurposeTo evaluate the outcomes of patients who underwent Gamma Knife radiosurgery (GKRS) for the treatment of cavernous sinus (CS) meningiomas.MethodsWe retrospectively reviewed the clinical and radiological outcomes of 95 patients with CS meningiomas at Taipei Veterans General Hospital between 1993 and 2011. The study cohort comprised 27 men and 68 women with a median age of 50years (range 29-79years). The median pre-GKRS tumor volume was 6.6ml (range 0.9-35.7ml). The median margin dose was 12Gy (range 11-21Gy). The clinical factors related to favorable outcomes were assessed.ResultsThe median follow-up period was 59 (range 12-209) months. At the final follow-up, the tumor volume regressed in 70 patients (74%) and progressed in eight (8%). Kaplan-Meier analysis revealed that the progression-free survival rates at 5 and 10years were 92.7% and 81.2%, respectively. Three patients (3.2%) experienced exacerbated cranial nerve dysfunction following radiosurgery. Confined tumors were found to be an independent prognostic factor for tumor control and shorter times to regression in the multivariable analyses. No risk factor for tumor progression was identified in either the univariate or multivariate analyses.ConclusionsGKRS provides good long-term tumor control and is associated with low cranial nerve-related morbidity development rates in patients with small- to medium-sized CS meningiomas. Confined tumor could be an independent prognostic factor for tumor control and shorter times to regression in multivariate analysis. Life-long follow-up is mandatory in such settings, even for outpatients with shrunken or stabilized tumors.
    關聯: Journal of Neuro-Oncology, v.143, n.2, pp.261-270
    Appears in Collections:[醫務管理系(所)] 期刊論文

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