Antimicrobial activities of ceftazidime-avibactam, ceftolozane-tazobactam, and other agents against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa isolated from intensive care units in Taiwan: results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan in 2016

doi:10.2147/IDR.S193638

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Title:	Antimicrobial activities of ceftazidime-avibactam, ceftolozane-tazobactam, and other agents against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa isolated from intensive care units in Taiwan: results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan in 2016
Authors:	Liao, Chun-Hsing Lee, Na-Yao Hung-Jen Tang(湯宏仁) Lee, Susan Shin-Jung Lin, Chin-Fu Lu, Po-Liang Wu, Jiunn-Jong Ko, Wen-Chien Lee, Wen-Sen Hsueh, Po-Ren
Contributors:	Far Eastern Mem Hosp, Dept Internal Med Yang Ming Univ, Dept Med Natl Cheng Kung Univ Med Coll & Hosp, Dept Internal Med Chi Mei Med Ctr, Dept Internal Med Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Kaohsiung Vet Gen Hosp, Dept Internal Med Natl Yang Ming Univ, Fac Med, Sch Med Taichung Vet Gen Hosp, Dept Pathol & Lab Med Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Coll Med, Dept Internal Med Kaohsiung Med Univ Hosp, Dept Lab Med Kaohsiung Med Univ, Grad Inst Med, Coll Med Natl Yang Ming Univ, Dept Biotechnol & Lab Sci Med Natl Cheng Kung Univ, Dept Med, Coll Med Taipei Med Univ, Wan Fang Med Ctr, Dept Internal Med, Div Infect Dis Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Lab Med, Coll Med Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Internal Med, Coll Med
Keywords:	carbapenem resistance second-generation beta-lactam beta-lactamase inhibitor combinations carbapenemase-encoding genes mcr
Date:	2019
Issue Date:	2020-07-29 13:48:46 (UTC+8)
Publisher:	DOVE MEDICAL PRESS LTD
Abstract:	Objective: The aim of this study was to investigate the in vitro antimicrobial susceptibilities of clinically important Gram-negative bacteria from seven intensive care units in Taiwan in 2016. Materials and methods: In total, 300 non-duplicate isolates of Escherichia coli (n=100), Klebsiella pneumoniae (n=100), and Pseudomonas aeruginosa (n=100) collected from 300 patients were studied. The minimum inhibitory concentrations (MICs) of these isolates to antimicrobial agents were determined using the broth microdilution method. Carbapenemase-encoding genes (bla(KPC), bla(NDM), bla(IMP), bla(VIM), and bla(OXA-48-like)) were studied for the isolates that were not susceptible to any carbapenems. Sequencing analysis of the mcr genes (mcr-1-5) was conducted for all isolates with colistin MICs >= 4 mg/L. Results: Ertapenem non-susceptibility was detected in 3% (n=3) E. coli and 12% (n=12) K. pneumoniae isolates. The susceptibility rates of imipenem, ceftazidime-avibactam (CAZ-AVB), and ceftolozane-tazobactam (CLZ-TAZ) were 99%, 99%, and 88%, respectively, for E. coli, 91%, 100%, and 80%, respectively, for K. pneumoniae, and 66%, 91%, and 93%, respectively, for P. aeruginosa. Carbapenemase-encoding genes were not detected in E. coli, were detected in four (33.3%) K. pneumoniae isolates that were not susceptible to ertapenem (three harboring bla(KPC) and one harboring bla(OXA-48-like)), and were not detected in P. aeruginosa isolates that were not susceptible to imipenem. One K. pneumoniae isolate was resistant to colistin (MIC 4 mg/L) and negative for mcr genes. Conclusion: CAZ-AVB exhibited excellent activity against carbapenem-resistant Enterobacteriaceae, and CLZ-TAZ exhibited good activity against imipenem-resistant P. aeruginosa.
Relation:	Infection and Drug Resistance, v.12, pp.545-552
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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