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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32532

    標題: Antimicrobial activities of ceftazidime-avibactam, ceftolozane-tazobactam, and other agents against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa isolated from intensive care units in Taiwan: results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan in 2016
    作者: Liao, Chun-Hsing
    Lee, Na-Yao
    Hung-Jen Tang(湯宏仁)
    Lee, Susan Shin-Jung
    Lin, Chin-Fu
    Lu, Po-Liang
    Wu, Jiunn-Jong
    Ko, Wen-Chien
    Lee, Wen-Sen
    Hsueh, Po-Ren
    貢獻者: Far Eastern Mem Hosp, Dept Internal Med
    Yang Ming Univ, Dept Med
    Natl Cheng Kung Univ Med Coll & Hosp, Dept Internal Med
    Chi Mei Med Ctr, Dept Internal Med
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Kaohsiung Vet Gen Hosp, Dept Internal Med
    Natl Yang Ming Univ, Fac Med, Sch Med
    Taichung Vet Gen Hosp, Dept Pathol & Lab Med
    Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Coll Med, Dept Internal Med
    Kaohsiung Med Univ Hosp, Dept Lab Med
    Kaohsiung Med Univ, Grad Inst Med, Coll Med
    Natl Yang Ming Univ, Dept Biotechnol & Lab Sci Med
    Natl Cheng Kung Univ, Dept Med, Coll Med
    Taipei Med Univ, Wan Fang Med Ctr, Dept Internal Med, Div Infect Dis
    Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Lab Med, Coll Med
    Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Internal Med, Coll Med
    關鍵字: carbapenem resistance
    beta-lactamase inhibitor combinations
    carbapenemase-encoding genes
    日期: 2019
    上傳時間: 2020-07-29 13:48:46 (UTC+8)
    摘要: Objective: The aim of this study was to investigate the in vitro antimicrobial susceptibilities of clinically important Gram-negative bacteria from seven intensive care units in Taiwan in 2016. Materials and methods: In total, 300 non-duplicate isolates of Escherichia coli (n=100), Klebsiella pneumoniae (n=100), and Pseudomonas aeruginosa (n=100) collected from 300 patients were studied. The minimum inhibitory concentrations (MICs) of these isolates to antimicrobial agents were determined using the broth microdilution method. Carbapenemase-encoding genes (bla(KPC), bla(NDM), bla(IMP), bla(VIM), and bla(OXA-48-like)) were studied for the isolates that were not susceptible to any carbapenems. Sequencing analysis of the mcr genes (mcr-1-5) was conducted for all isolates with colistin MICs >= 4 mg/L. Results: Ertapenem non-susceptibility was detected in 3% (n=3) E. coli and 12% (n=12) K. pneumoniae isolates. The susceptibility rates of imipenem, ceftazidime-avibactam (CAZ-AVB), and ceftolozane-tazobactam (CLZ-TAZ) were 99%, 99%, and 88%, respectively, for E. coli, 91%, 100%, and 80%, respectively, for K. pneumoniae, and 66%, 91%, and 93%, respectively, for P. aeruginosa. Carbapenemase-encoding genes were not detected in E. coli, were detected in four (33.3%) K. pneumoniae isolates that were not susceptible to ertapenem (three harboring bla(KPC) and one harboring bla(OXA-48-like)), and were not detected in P. aeruginosa isolates that were not susceptible to imipenem. One K. pneumoniae isolate was resistant to colistin (MIC 4 mg/L) and negative for mcr genes. Conclusion: CAZ-AVB exhibited excellent activity against carbapenem-resistant Enterobacteriaceae, and CLZ-TAZ exhibited good activity against imipenem-resistant P. aeruginosa.
    關聯: Infection and Drug Resistance, v.12, pp.545-552
    Appears in Collections:[保健營養系(所) ] 期刊論文

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