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| 標題: | Clinical manifestations of candidemia caused by uncommon Candida species and antifungal susceptibility of the isolates in a regional hospital in Taiwan, 2007-2014 |
| 作者: | Liu, Wei-Lun
Lai, Chih-Cheng
Li, Ming-Chi
Wu, Chi-Jung
Ko, Wen-Chien
Hung, Yi-Li
Hung-Jen Tang(湯宏仁)
Hsueh, Po-Ren |
| 貢獻者: | Fu Jen Catholic Univ Hosp, Dept Emergency & Crit Care Med
Fu Jen Catholic Univ, Coll Med
Chi Mei Med Ctr, Dept Intens Care Med
Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med
Natl Cheng Kung Univ Hosp, Ctr Infect Control
Natl Hlth Res Inst, Natl Inst Infect Dis & Vaccinol
Cathay Gen Hosp, Dept Pediat
Chi Mei Med Ctr, Dept Internal Med
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Lab Med
Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Internal Med |
| 關鍵字: | Candidemia
Uncommon candida species
Healthcare-associated infection
Antifungal susceptibility testing
Azotes
Echinocandin |
| 日期: | 2019-08 |
| 上傳時間: | 2020-07-29 13:48:44 (UTC+8) |
| 出版者: | ELSEVIER TAIWAN |
| 摘要: | Objective: This retrospective study investigated clinical manifestations of candidemia caused by uncommon Candida species and antifungal susceptibility of the isolates in a regional hospital in Taiwan. Methods: The uncommon Candida species was initially defined as Candida species other than C. albicans, C. tropicalis, C. glabrata complex, C. parapsilosis complex and C. krusei. All uncommon Candida isolates were identified and confirmed by molecular methods. In vitro susceptibility testing of the uncommon Candida species to nine antifungal agents was conducted using the broth microdilution method with the Sensititre YeastOne (SYO) system (Trek Diagnostic Systems, Ltd., East Grimstead, UK). Results: Twenty-one patients, comprising 11 males and 10 females with a median age of 69 years, were recruited. Cancer (n = 11) was the most common underlying disease, 19 (90.5%) cases had prior antibiotic exposure, and only two patients had prior antifungal use. The overall in-hospital mortality rate was 38.1% (n = 8). C. guilliermondii (n = 11) was the most common pathogen, followed by C. curvata (n = 3). C. guilliermondii isolates exhibited relatively high rates of azole minimum inhibitory concentrations (MICs) above epidemiological cut-off values (ECVS), whereas C. pelliculosa and C. lusitaniae isolates all remained susceptible to azoles. All three C. curvata isolates had high caspofungin (>8 mg/L) and fluconazole MICs (8 mg/L) and could be defined as multidrug-resistant. Conclusions: Uncommon Candida species frequently exhibit high rates of non-susceptibility to antifungals. Identification of all Candida isolates at the species level from blood samples is of value for treatment. Copyright (C) 2017, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. |
| 關聯: | Journal of Microbiology Immunology and Infection, v.52, n.4, pp.612-619 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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