Subcutaneous brompheniramine for cutaneous analgesia in rats

doi:10.1016/j.ejphar.2019.172544

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標題:	Subcutaneous brompheniramine for cutaneous analgesia in rats
作者:	Chiu, Chong-Chi Jen-Yin Chen(陳貞吟) Chen, Yu-Wen Wang, Jhi-Joung Hung, Ching-Hsia
貢獻者:	Chi Mei Med Ctr, Dept Gen Surg Chi Mei Med Ctr, Dept Gen Surg Southern Taiwan Univ Sci & Technol, Dept Elect Engn Chi Mei Med Ctr, Dept Anesthesiol Chia Nan Univ Pharm & Sci, Dept Senior Citizen Serv Management Chi Mei Med Ctr, Dept Med Res China Med Univ, Coll Hlth Care, Dept Phys Therapy Southern Taiwan Univ Sci & Technol, Allied AI Biomed Ctr Natl Cheng Kung Univ, Coll Med, Dept Phys Therapy Natl Cheng Kung Univ, Coll Med, Inst Allied Hlth Sci
關鍵字:	Brompheniramine Mepivacaine Skin antinociception Pinpricks
日期:	2019-10
上傳時間:	2020-07-29 13:48:35 (UTC+8)
出版者:	ELSEVIER
摘要:	Brompheniramine as an antihistamine blocked sodium channels, and local anesthetics by blocking sodium channels produced the local anesthetic effects. The authors aimed to assess local anesthetic quality and duration of brompheniramine when compared to the local anesthetic mepivacaine. After rats were shaved and injected subcutaneously on the dorsal skin, the panniculus reflex, induced via applying a noxious pinprick to the skin (injected area), was scored. The dose-response curve and nociceptive block duration of brompheniramine were constructed and compared with mepivacaine. The cutaneous analgesic effects in both brompheniramine and mepivacaine groups were concentration-dependent. On the basis of the amount required to produce a 50% block effect (ED50, 50% effective dose), the drug's potency was brompheniramine (0.89 [0.82-0.96] mu mol) better than mepivacaine (2.45 [2.17-2.76] mu mol) (P < 0.01). Full recovery time of brompheniramine was more prolonged than mepivacaine's (P < 0.01) on infiltrative cutaneous analgesia when comparing ED(25)s, ED(50)s and ED(75)s. Our preclinical data demonstrated that subcutaneous brompheniramine induces dose-relatedly analgesic effects, and brompheniramine induces prolonged analgesic duration when compared with mepivacaine. Brompheniramine also provokes better cutaneous analgesia than mepivacaine.
關聯:	European Journal of Pharmacology, v.860, 172544
显示于类别:	[高齡福祉養生管理系] 期刊論文

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