Djulis (Chenopodium formosanum) and its bioactive compounds affect vasodilation, angiotensin converting enzyme activity, and hypertension

doi:10.1016/j.fbio.2019.100469

CNU IR > Pharmacy and Science > Dept. of Food Science & Technology > Periodical Articles > Item 310902800/32505

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/32505

Title:	Djulis (Chenopodium formosanum) and its bioactive compounds affect vasodilation, angiotensin converting enzyme activity, and hypertension
Authors:	Chen, Shih-Ying Chu, Chin-Chen Chyau, Charng-Cherng Yang, Jing-Wen Pin-Der Duh(杜平悳)
Contributors:	Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr, Tainan, Taiwan Chi Mei Med Ctr, Dept Anesthesiol Hungkuang Univ, Res Inst Biotechnol Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
Keywords:	Angiotensin-converting enzyme Antihypertensive effect Djulis Chenopodium formosanum Nitric oxide Prostacyclin Vasodilative effect
Date:	2019-12
Issue Date:	2020-07-29 13:47:43 (UTC+8)
Publisher:	ELSEVIER
Abstract:	Djulis (Chenopodium formosanum) and its bioactive compounds' effect on vasodilation, angiotensin-converting enzyme activity (ACE) and hypertension, in vitro and in vivo, were evaluated. Rutin, betanin and another 13 compounds were observed in the water extracts of djulis (WECF) using HPLC-DAD and HPLC-MS/MS analysis. WECF, rutin and betanin showed significant induction of nitric oxide and prostacyclin as well as expression of eNOS and COX-2. In addition, WECF, rutin and betanin showed a marked inhibitory effect on ROS generation, peroxynitrite levels and ACE activity. Oral administration of WECF, rutin and betanin lowered systolic and diastolic blood pressures of spontaneously hypertensive rats. The ACE activity in the plasma of WECF-, betanin- and rutin-administrated groups was lower than the untreated group. Overall, WECF bioactive compounds could potentially be used as functional ingredients for preventing hypertension.
Relation:	Food Bioscience, v.32, UNSP 100469
Appears in Collections:	[Dept. of Food Science & Technology] Periodical Articles

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