Traumatic Brain Injury Increases the Risk of Major Adverse Cardiovascular and Cerebrovascular Events: A 13-Year, Population-Based Study

doi:10.1016/j.wneu.2018.10.130

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標題:	Traumatic Brain Injury Increases the Risk of Major Adverse Cardiovascular and Cerebrovascular Events: A 13-Year, Population-Based Study
作者:	Nyam, Tee-Tau Eric Chung-Han Ho(何宗翰) Chio, Chung-Ching Lim, Sher-Wei Wang, Jhi-Joung Chang, Ching-Hung Kuo, Jinn-Rung Wang, Che-Chuan
貢獻者:	Chi Mei Med Ctr, Dept Neurosurg Chi Mei Med Ctr, Dept Med Res Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm Southern Taiwan Univ Sci & Technol, Dept Biotechnol Southern Taiwan Univ Sci & Technol, Ctr Gen Educ
關鍵字:	ACCI Cardiovascular Mortality MACCE Stroke Traumatic brain injury
日期:	2019-02
上傳時間:	2020-07-29 13:47:10 (UTC+8)
出版者:	ELSEVIER SCIENCE INC
摘要:	BACKGROUND: Previous studies have indicated traumatic brain injury (TBI) as a risk factor for stroke and myocardial injury. Whether TBI increases new onset of major adverse cardiovascular and cerebrovascular events (MACCE) is not well established. METHODS: Patients with a diagnosis of TBI from 2000 to 2012 were 1: 2 age-, sex-, and age-adjusted comorbidities matched with normal population cohorts. The MACCE, which included coronary artery disease, heart failure and arrhythmia, ischemic and hemorrhagic stroke, and death, was defined as one inpatient admission with MACCE diagnosis. The maximum follow-up duration to MACCE after the initial TBI diagnosis was 5 years. The baseline comorbidities before TBI, including hypertension, diabetes mellitus, renal disease, and liver disease, also were considered to estimate the risk of MACCE. RESULTS: In total, 16,211 patients with TBI and 32,422 people from the control group were enrolled in the current study. Our results showed that patients with TBI had a 2.77-fold risk of MACCE, 1.72-fold risk of cardiovascular disease, 2.10-fold risk of ischemic stroke, 6.02-fold risk of hemorrhagic stroke, and 3.13-fold risk of mortality compared with the control group (all P < 0.0001) after adjusting the confounding factors. In addition, the trend of cumulated incidence risk among MACCE, cardiovascular disease, ischemic and hemorrhagic stroke, and mortality presented the greatest incidence within the first year after diagnosis and persisted during the 5 years of follow-up. CONCLUSIONS: Our results showed that patients with TBI have a significantly greater risk of MACCE than the control group. We hope this information will remind critical-care physicians and neurosurgeons to keep in mind the long-term effects of TBI on MACCE.
關聯:	World Neurosurgery, v.122, pp.E740-E753
显示于类别:	[醫務管理系(所)] 期刊論文

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