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| 標題: | Loss of cyclin-dependent kinase-like 2 predicts poor prognosis in gastric cancer, and its overexpression suppresses cells growth and invasion |
| 作者: | Fang, Chia-Lang
Uen, Yih-Huei
Chen, Han-Kun
Hseu, You-Cheng
Lin, Chih-Chan
Hung, Shih-Ting
Sun, Ding-Ping
Lin, Kai-Yuan |
| 貢獻者: | Taipei Med Univ, Coll Med, Sch Med, Dept Pathol
Taipei Med Univ, Wan Fang Hosp, Dept Pathol
Asia Univ Hosp, Dept Surg
Chi Mei Med Ctr, Dept Surg
China Med Univ, Dept Cosmeceut
Asia Univ, Dept Hlth & Nutr Biotechnol
Chi Mei Med Ctr, Dept Med Res
Chia Nan Univ Pharm & Sci, Dept Nutr
Chia Nan Univ Pharm & Sci, Dept Biotechnol |
| 關鍵字: | CDKL2
gastric cancer
immunohistochemistry
prognosis |
| 日期: | 2018-07 |
| 上傳時間: | 2019-11-15 15:49:00 (UTC+8) |
| 出版者: | WILEY |
| 摘要: | Cyclin-dependent kinase-like 2 (CDKL2), a new member of the cyclin-dependent kinase family, may be involved in gastric cancer (GC) progression. Thus, we conducted this study to explore the clinical effect of CDKL2 in GC. Immunohistochemistry was used to measure CDKL2 levels in gastric tissues. The association of a high CDKL2 level with clinical and pathological characteristics, and the correlation between the CDKL2 level and disease-free and overall survival were analyzed. Transfection was employed to overexpress CDKL2 in GC cells and to investigate the effect of CDKL2 overexpression on cell proliferation and invasion. Loss of CDKL2 was positively correlated with several clinical and pathological characteristics, and patients with a low CDKL2 level had significantly poorer disease-free and overall survival than those with a high level (P=.005 and .001, respectively). Univariate analysis using the Cox proportional hazards model indicated that a low CDKL2 level was a prognosticator for inferior disease-free survival (P=.007). Based on immmunoblotting data, AGS and HGC-27 GC cells were chosen for CDKL2 overexpression. Cellular studies revealed that CDKL2 overexpression impaired cell proliferation and invasion. Loss of CDKL2 may serve as a biomarker for predicting GC patient outcomes and a potential therapeutic target for GC treatment. |
| link: | http://dx.doi.org/10.1002/cam4.1577 |
| 關聯: | Indian Journal of Pharmaceutical Sciences, v.7, n.7, pp.2993-3002 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
[生物科技系(所)] 期刊論文
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