Adipose-derived stem cells decrease cardiomyocyte damage induced by porphyromonas gingivalis endotoxin through suppressing hypertrophy, apoptosis, fibrosis, and MAPK markers

doi:10.1002/tox.22536

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標題:	Adipose-derived stem cells decrease cardiomyocyte damage induced by porphyromonas gingivalis endotoxin through suppressing hypertrophy, apoptosis, fibrosis, and MAPK markers
作者:	Chen, Tung-Sheng Kuo, Chia-Hua Battsengel, Sarnai Pan, Lung-Fa Day, Cecilia Hsuan Shen, Chia-Yao Chung, Li-Chin Padma, V. Vijaya Yao, Chen-Kai Lin, Yueh-Min Huang, Chih-Yang
貢獻者:	Natl Taiwan Normal Univ, Sch Life Sci China Med Univ, Grad Inst Basic Med Sci Univ Taipei, Dept Sports Sci Intermed Hosp Armed Force Taichung Gen Hosp, Div Cardiol Univ Sci & Technol, Dept Med Imaging & Radiol Sci Cent Taiwan MeiHo Univ, Dept Nursing Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm Bharathiar Univ, Dept Biotechnol Washington High Sch Changhua Christian Hosp, Dept Pathol Jen Teh Jr Coll Med Nursing & Management China Med Univ, Grad Inst Chinese Med Sci Ton Duc Thang Univ, Fac Appl Sci, Tan Phong Ward China Med Univ, Grad Inst Chinese Med Sci Asia Univ, Dept Hlth & Nutr Biotechnol
關鍵字:	cardiomyopathy endotoxin IGF1 periodontal disease stem cell
日期:	2018-04
上傳時間:	2019-11-15 15:48:46 (UTC+8)
出版者:	WILEY
摘要:	Heart failure is one of the complications related to periodontal disease. In addition to drugs or herbal medicines, stem cell therapy shows potential in the treatment of cardiomyopathy. This study investigates if stem cells exhibit beneficial effects on cardiomyocyte damage induced by porphyromonas gingivalis endotoxin (Pg-LPS). From the experimental results we find that Pg-LPS reduce cardiomyocyte viability via the activation of apoptosis, hypertrophy, fibrosis and MAPK signaling. Pg-LPS damaged cardiomyocytes co-cultured with adipose-derived stem cells (ADSC) increases cardiomyocyte viability through suppressing the pathological markers described above. Further evidence implies that survival marker, IGF1, secreted from ADSC, may play an important role in the Pg-LPS induced protective effect on cardiomyocyte damage.
link:	http://dx.doi.org/10.1002/tox.22536
關聯:	Scientific Reports, v.33, n.4, pp.508-513
顯示於類別:	[醫務管理系(所)] 期刊論文

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