Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/32297
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    標題: Prevalence, mechanisms and genetic relatedness of the human pathogenic fungus Aspergillus fumigatus exhibiting resistance to medical azoles in the environment of Taiwan
    作者: Wang, Hsuan-Chen
    Huang, Jui-Chang
    Lin, Yong-Hong
    Chen, Yu-Hsin
    Hsieh, Ming-I
    Choi, Pui-Ching
    Lo, Hsiu-Jung
    Liu, Wei-Lun
    Hsu, Ching-Shan
    Shih, Hsin-I
    Wu, Chi-Jung
    Chen, Yee-Chun
    貢獻者: Natl Hlth Res Inst, Natl Inst Infect Dis & Vaccinol, Div Infect Dis
    Council Agr, Execut Yuan, Tainan Dist Agr Res & Extens Stn, Div Crop Environm
    Council Agr, Execut Yuan, Kaohsiung Dist Agr Res & Extens Stn, Div Crop Environm
    Council Agr, Execut Yuan, Taichung Dist Agr Res & Extens Stn, Div Crop Improvement
    China Med Univ, Sch Dent
    Fu Jen Catholic Univ Hosp, Dept Emergency & Crit Care Med
    Fu Jen Catholic Univ, Coll Med, Sch Med
    Chia Nan Univ Pharm & Sci, Dept Environm Resource Management
    Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Emergency Med
    Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Internal Med
    Natl Taiwan Univ Hosp, Dept Internal Med
    關鍵字: Tr34/L98H Mutations
    Invasive Aspergillosis
    Cyp51A Gene
    Itraconazole
    Transporter
    Epidemiology
    日期: 2018-01
    上傳時間: 2019-11-15 15:48:35 (UTC+8)
    出版者: WILEY
    摘要: Emerging azole resistance in Aspergillus fumigatus poses a serious threat to human health. This nationwide surveillance study investigated the prevalence and molecular characteristics of azole-resistant A. fumigatus environmental isolates in Taiwan, an island country with increasing use of azole fungicides. Of the 2760 air and soil samples screened from 2014 to 2016, 451 A. fumigatus isolates were recovered from 266 samples and 34 isolates from 29 samples displayed resistance to medical azoles (itraconazole, voriconazole or posaconazole). The resistance prevalence was 10.9% and 7.5% in A. fumigatus-positive samples and isolates respectively. Most (29, 85.3%) azole-resistant isolates harboured TR34/L98H mutations, which were widely distributed, clustered genetically with clinical isolates, and had growth rates that were similar to those of the wild-type isolates. Microsatellite genotyping revealed both the global spread of the TR34/L98H isolates and the occurrence of TR34/L98H/S297T/F495I isolates belonging to local microsatellite genotypes. AfuMDR3 and atrF, two efflux transporter genes, were constitutively upregulated in two individual resistant isolates without cyp51A mutations, highlighting their potential roles in azole resistance. These results emphasize the need for periodic environmental surveillance at the molecular level in regions in which azole fungicides are applied, and agricultural fungicide management strategies that generate less selective pressure should be investigated.
    關聯: Journal of Cellular and Molecular Medicine, v.20, n.1, pp.270-280
    显示于类别:[環境資源管理系(所)] 期刊論文

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