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| 標題: | Prevalence, mechanisms and genetic relatedness of the human pathogenic fungus Aspergillus fumigatus exhibiting resistance to medical azoles in the environment of Taiwan |
| 作者: | Wang, Hsuan-Chen
Huang, Jui-Chang
Lin, Yong-Hong
Chen, Yu-Hsin
Hsieh, Ming-I
Choi, Pui-Ching
Lo, Hsiu-Jung
Liu, Wei-Lun
Hsu, Ching-Shan
Shih, Hsin-I
Wu, Chi-Jung
Chen, Yee-Chun |
| 貢獻者: | Natl Hlth Res Inst, Natl Inst Infect Dis & Vaccinol, Div Infect Dis
Council Agr, Execut Yuan, Tainan Dist Agr Res & Extens Stn, Div Crop Environm
Council Agr, Execut Yuan, Kaohsiung Dist Agr Res & Extens Stn, Div Crop Environm
Council Agr, Execut Yuan, Taichung Dist Agr Res & Extens Stn, Div Crop Improvement
China Med Univ, Sch Dent
Fu Jen Catholic Univ Hosp, Dept Emergency & Crit Care Med
Fu Jen Catholic Univ, Coll Med, Sch Med
Chia Nan Univ Pharm & Sci, Dept Environm Resource Management
Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Emergency Med
Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Internal Med
Natl Taiwan Univ Hosp, Dept Internal Med |
| 關鍵字: | Tr34/L98H Mutations
Invasive Aspergillosis
Cyp51A Gene
Itraconazole
Transporter
Epidemiology |
| 日期: | 2018-01 |
| 上傳時間: | 2019-11-15 15:48:35 (UTC+8) |
| 出版者: | WILEY |
| 摘要: | Emerging azole resistance in Aspergillus fumigatus poses a serious threat to human health. This nationwide surveillance study investigated the prevalence and molecular characteristics of azole-resistant A. fumigatus environmental isolates in Taiwan, an island country with increasing use of azole fungicides. Of the 2760 air and soil samples screened from 2014 to 2016, 451 A. fumigatus isolates were recovered from 266 samples and 34 isolates from 29 samples displayed resistance to medical azoles (itraconazole, voriconazole or posaconazole). The resistance prevalence was 10.9% and 7.5% in A. fumigatus-positive samples and isolates respectively. Most (29, 85.3%) azole-resistant isolates harboured TR34/L98H mutations, which were widely distributed, clustered genetically with clinical isolates, and had growth rates that were similar to those of the wild-type isolates. Microsatellite genotyping revealed both the global spread of the TR34/L98H isolates and the occurrence of TR34/L98H/S297T/F495I isolates belonging to local microsatellite genotypes. AfuMDR3 and atrF, two efflux transporter genes, were constitutively upregulated in two individual resistant isolates without cyp51A mutations, highlighting their potential roles in azole resistance. These results emphasize the need for periodic environmental surveillance at the molecular level in regions in which azole fungicides are applied, and agricultural fungicide management strategies that generate less selective pressure should be investigated. |
| 關聯: | Journal of Cellular and Molecular Medicine, v.20, n.1, pp.270-280 |
| 顯示於類別: | [環境資源管理系(所)] 期刊論文
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