MicroRNA-21 is Associated with the Severity of Right Ventricular Dysfunction in Patients with Hypoxia-Induced Pulmonary Hypertension

doi:10.6515/ACS.201811_34(6).20180613A

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Title:	MicroRNA-21 is Associated with the Severity of Right Ventricular Dysfunction in Patients with Hypoxia-Induced Pulmonary Hypertension
Authors:	Chang, Wei-Ting Hsu, Chih-Hsin Huang, Tzu-Ling Tsai, Ying-Ching Chiang, Chun-Yen Chen, Zhih-Cherng Shih, Jhih-Yuan
Contributors:	Chi Mei Med Ctr, Dept Internal Med, Div Cardiol Southern Taiwan Univ Sci & Technol, Dept Biotechnol Cheng Kung Univ Hosp, Dept Intens Care Med Chia Nan Univ Pharm & Sci, Dept Pharm
Keywords:	Hypoxia-induced pulmonary hypertension miR-21 Right ventricular dysfunction
Date:	2018-11
Issue Date:	2019-11-15 15:48:14 (UTC+8)
Publisher:	TAIWAN SOC CARDIOLOGY
Abstract:	Background: The outcome of pulmonary hypertension (PH) mainly depends on the development of right ventricular (RV) dysfunction, and survival among patients with different etiologies of PH varies. Chronic hypoxia is a major cause of secondary PH, however the mechanisms of its associated RV dysfunction are largely unknown. Herein, we studied the role of microRNA-21 (miR-21) in hypoxia-induced RV dysfunction. Methods: In this longitudinal, prospective study, we enrolled 41 patients with hypoxia-induced PH. Echocardiography was conducted and circulating miR-21 was measured. The expression of miR-21 was also evaluated in hypoxiatreated human pulmonary microvascular endothelial cells (HPECs) and conditioned media. Through the over expression of miR-21 in H9C2 cells, we further identified crosstalk between the pulmonary circulation and RV. Results: Among the studied patients, 10 developed RV dysfunction. Notably, the expression of circulating miR-21 was correlated with the severity of RV dysfunction. Likewise, miR-21 was up-regulated in the hypoxia-treated HPECs and its conditioned media in a time-dependent manner. I addition, hypertrophic changes were observed in the hypoxia-treated HPECs. The up-regulation of heart failure-associated markers in H9C2 cells over-expressing miR-21 implied the influence of pulmonary circulatory miR-21 on RV function. Conclusions: The expression of systemic and pulmonary miR-21 is associated with the severity of RV dysfunction in patients with hypoxia-induced PH.
???metadata.dc.relation.uri???:	http://dx.doi.org/10.6515/ACS.201811_34(6).20180613A
Relation:	Journal of Microbiology Immunology and Infection, v.34, n.6, pp.511-517
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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