Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/32287
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    標題: Antioxidant and anti-inflammatory capacities of collagen peptides from milkfish (Chanos chanos) scales
    作者: Chen, Yu-Pei
    Liang, Chia-Hua
    Wu, Hong-Tan
    Pang, Hai-Yue
    Chen, Chuan
    Wang, Guey-Horng
    Chan, Leong-Perng
    貢獻者: Xiamen Med Coll, Res Ctr Nat Cosmeceut Engn
    Xiamen Med Coll, Coll Fuijan Prov, Applicat Tech Engn Ctr Nat Cosmeceut
    Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
    Chia Nan Univ Pharm & Sci, Inst Cosmet Sci
    Xiamen Med Coll, Dept Pharm
    Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Otolaryngol Head & Neck Surg
    關鍵字: Milkfish
    Fish scale
    Collagen peptide
    日期: 2018-06
    上傳時間: 2019-11-15 15:48:12 (UTC+8)
    摘要: Milkfish (Chanos chanos), which is resistant to water quality changes is the fourth largest aquaculture commodity. Abandoned wastes of fish scale and bones aggravate environmental pollution. In this study, the effect of collagen peptides isolated from milkfish scales (MSCP) by pepsin-soluble collagen method on cell viability was investigated. The antioxidant, anti-inflammatory, and DNA-protective activities of MSCP were also evaluated. Results revealed that more than 95% of viable cells were retained in human keratinocytes after addition of 100 mg/mL MSCP. Measurement of DPPH center dot and ABTS center dot + radical scavenging activities and cellular reactive oxygen species revealed the high antioxidant activities of MSCP. MSCP demonstrated anti-inflammatory activities by reducing lipoxygenase activity and nitric oxide (NO center dot) radicals. Moreover, DNA electrophoresis assay indicated that MSCP treatment can directly protect against cyclobutane di-pyrimidine production and DNA single-strand breaks, which are harmful effects of UV radiation and H2O2. Given its antioxidant, anti-inflammatory, and DNA-protective activities, MSCP has potential applications in cosmeceuticals and supplementary health food.
    關聯: Acta Cardiologica Sinica, v.55, n.6, pp.2310-2317
    显示于类别:[化妝品應用與管理系(所)] 期刊論文


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