Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/32271
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    標題: Preventive effects of taurine against D-galactose-induced cognitive dysfunction and brain damage
    作者: Tu, Dom-Gene
    Chang, Yao-Ling
    Chou, Chung-Hsi
    Lin, Yi-Ling
    Chiang, Chia-Chun
    Chang, Yuan-Yen
    Chen, Yi-Chen
    貢獻者: Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Nucl Med
    Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
    Chang Jung Christian Univ, Coll Hlth Sci
    Natl Taiwan Univ, Dept Anim Sci & Technol
    Natl Taiwan Univ, Sch Vet Med
    Natl Taiwan Univ, Zoonoses Res Ctr
    Chung Jen Jr Coll Nursing Hlth Sci & Management, Dept Nursing
    Chung Shan Med Univ, Sch Med, Dept Microbiol & Immunol
    Chung Shan Med Univ Hosp, Clin Lab
    關鍵字: Oxidative Stress
    Advanced Glycation
    Aging Model
    Mouse Model
    日期: 2018-01
    上傳時間: 2019-11-15 15:47:37 (UTC+8)
    摘要: Oxidative stress arising from life processes or environmental influences and its resultant cellular dysfunctions are major causes of neurodegenerative disorders. The objectives of this study were to investigate whether taurine (Tau) can prevent D-galactose-induced cognitive dysfunction and brain oxidative damage. Mice given with Tau supplementation (100 and 400 mg per kg BW per day) spent shorter (p < 0.05) time in searching target in D-galactose (100 mg per kg BW per day) treated mice in a water maze reference memory experiment. Moreover, Tau supplementation extended (p < 0.05) the searching period around the target quadrant in the probe test of the water maze, and neuronal degeneration and nucleus shrinkage in the hippocampus dentate gyrus area of D-galactose treated mice were observed to be attenuated. Tau also downregulated (p < 0.05) expression of the glial fibrillary acidic protein (Gfap) and of the cluster of differentiation marker Cd11b; meanwhile, it strengthened (p < 0.05) antioxidant capacity and lowered (p < 0.05) the accumulation of advanced glycation end-products (AGEs) in the brain. Therefore, Tau could be effective to ameliorate oxidative damage and inflammation in the brain, and apoptosis of brain cells, which further lessen the cognitive dysfunction.
    關聯: Food & Function, v.9, n.1, pp.124-133
    显示于类别:[ 食品科技系 ] 期刊論文


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