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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32268

    標題: Risk of retinal artery occlusion in patients with diabetes mellitus: A retrospective large-scale cohort study
    作者: Chang, Yuh-Shin
    Ho, Chung-Han
    Chu, Chin-Chen
    Wang, Jhi-Joung
    Tseng, Sung-Huei
    Jan, Ren-Long
    貢獻者: Chi Mei Med Ctr, Dept Ophthalmol
    Chang Jung Christian Univ, Grad Inst Med Sci, Coll Hlth Sci
    Chi Mei Med Ctr, Dept Med Res
    Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
    Chi Mei Med Ctr, Dept Anesthesiol
    Chia Nan Univ Pharm & Sci, Dept Recreat & Hlth Care Management
    Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Dept Ophthalmol, Coll Med
    Chi Mei Med Ctr, Dept Pediat
    關鍵字: Insulin-Resistance
    Endothelial Dysfunction
    Metabolic Syndrome
    Oxidative Stress
    Vessel Caliber
    日期: 2018-08-09
    上傳時間: 2019-11-15 15:47:30 (UTC+8)
    摘要: There is a globally increasing prevalence and incidence of diabetes mellitus (DM). Prolonged hyperglycaemia could lead to both macrovascular damage, such as carotid artery atherosclerosis, and microvascular damage, such as retinal arteriolar narrowing, and might contribute to retinal artery occlusion (RAO). Accordingly, it is important to determine whether DM is a contrubuting factor of RAO. We conducted a retrospective cohort study that included 241,196 DM patients from the Longitudinal Cohort of Diabetes Patients Database who were recruited between 2003 and 2005. An age- and sex-matched non-DM control group included the same number of patients who were selected from the Taiwan Longitudinal Health Insurance Database of 2000. Relevant data of each patient were collected from the index date until December 2013. The incidence and risk of RAO were calculated and compared between the DM and non-DM groups. The hazard ratio for RAO was calculated using Cox proportional hazards regression analysis after adjusting for confounders. The cumulative incidence rate of RAO was calculated by Kaplan Meier analysis. In total, 317 patients with DM and 144 controls developed RAO during the follow-up period, leading to an incidence rate of RAO in DM patients that was 2.30 times (95% confidence interval [CI] = 1.89-2.80) greater than that in controls. After adjustment for potential confounders, patients with DM were 2.11 times (95% CI, 1.71-2.59) more likely to develop RAO in the total study cohort. In conclusion, DM increases the risk of RAO, which is an interdisciplinary emergency. Close collaboration between endocrinologists and ophthalmologists is important in managing RAO following DM.
    link: http://dx.doi.org/10.1371/journal.pone.0201627
    關聯: Plos One, v.13, n.8, e0201627
    Appears in Collections:[休閒保健管理系(所)] 期刊論文

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