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| 標題: | Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation |
| 作者: | Weng, Tzu-Yang
Wu, Hsuan Franziska
Li, Chung-Yen
Hung, Yu-Hsuan
Chang, Yu-Wei
Chen, Yi-Ling
Hsu, Hui-Ping
Chen, Yu-Hung
Wang, Chih-Yang
Chang, Jang-Yang
Lai, Ming-Derg |
| 貢獻者: | Natl Cheng Kung Univ, Coll Med, Dept Biochem & Mol Biol
Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Surg
Natl Cheng Kung Univ, Dept Med
Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci
Chia Nan Univ Pharm & Sci, Dept Senior Citizen Serv Management
Natl Hlth Res Inst, Natl Inst Canc Res |
| 關鍵字: | Antigen-Presenting Cells
B-Cells
Translational Control
Myeloid-Leukemia
Stat3 Activation
Signal Pathway
In-Vitro
Cancer
Apoptosis
Chemotherapy |
| 日期: | 2018-05-29 |
| 上傳時間: | 2019-11-15 15:47:02 (UTC+8) |
| 出版者: | NATURE PUBLISHING GROUP |
| 摘要: | Homoharringtonine (HHT), an inhibitor of protein synthesis, has been used to treat leukemia. Its therapeutic effects on non-small cell lung adenocarcinoma carrying KRAS mutation and their immune system are less understood. The present study examined the therapeutic efficacy and the immune effects of HHT in two murine lung tumor models, xenograft and transgenic, carrying the Kras mutation G12D and G12C respectively. HHT exhibited efficient anticancer activity, significantly suppressing lung tumor growth in vitro and in vivo. The levels of 22 cytokines and chemokines in splenocytes of tumor-bearing mice were examined. Interleukin-12 expression was lower in splenocytes of HHT-treated mice when compared to the controls as demonstrated by a cytokine array and an enzyme-linked immunosorbent assay. The expression levels of CD80, CD86, and CD69 in B220(+) B cells from splenocytes of HHT-treated mice were higher than that of control mice in two mouse tumor models. Furthermore, antitumor effect of HHT was attenuated with depletion of B cells. Increased numbers of CD80(+) and CD86(+) B cells were observed in the mice treated with narciclasine, another translation inhibitor. In conclusion, HHT changed the features of immune cells, and exhibited efficient anti-tumor activity against lung tumor carrying mutant Kras expression. |
| link: | http://dx.doi.org/10.1038/s41598-018-26454-w |
| 關聯: | Scientific Reports, v.8, 8216 |
| 顯示於類別: | [高齡福祉養生管理系] 期刊論文
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