Mortality Risks among Various Primary Renal Diseases in Children and Adolescents on Chronic Dialysis

doi:10.3390/jcm7110414

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Title:	Mortality Risks among Various Primary Renal Diseases in Children and Adolescents on Chronic Dialysis
Authors:	Chou, Hsin-Hsu Chiou, Yuan-Yow Chiou, Yee-Hsuan Tain, You-Lin Wang, Hsin-Hui Yu, Mei-Ching Hsu, Chih-Cheng Lin, Ching-Yuang
Contributors:	Chia Yi Christian Hosp, Dept Pediat, Ditmanson Med Fdn Chia Nan Univ Pharm & Sci, Coll Human Ecol, Dept Appl Life Sci & Hlth Natl Cheng Kung Univ, Inst Clin Med, Med Coll & Hosp, Dept Pediat Kaohsiung Vet Gen Hosp, Dept Pediat, Fooyin Univ, Dept Med Technol Chang Gung Mem Hosp, Div Pediat Nephrol, Kaohsiung Med Ctr Taipei Vet Gen hosp, Dept Pediat Chang Gung Mem Hosp, Div Pediat Nephrol, Linko Med Ctr Chang Gung Univ Natl Hlth Res Inst, Inst Populat Heath Sci Natl Yang Ming Univ, Inst Clin Med China Med Univ, Dept Hlth Serv Adm China Med Univ, Clin Immunol Ctr, Med Coll & Hosp
Keywords:	mortality risk primary renal disease end-stage renal disease chronic dialysis children and adolescents
Date:	2018-11
Issue Date:	2019-11-15 15:46:29 (UTC+8)
Publisher:	MDPI
Abstract:	There is little information available on the association between primary renal disease (PRD) and long-term mortality in the pediatric dialysis population. The objective of this study was to explore mortality risks in children and adolescents on chronic dialysis, specifically focused on the risk of various PRDs. The study cohort included children and adolescents with end-stage renal disease (ESRD) (aged < 20 years) who had received dialysis for at least 90 days between 2000 and 2014 and were identified from Taiwan's National Health Insurance medical claims. A total of 530 children and adolescents were included in the study. The median age of the included patients was 13.6 years and 305 (57.5%) patients were males. One hundred and seven patients died during the follow-up period and the median survival time was 6.0 years. Mortality was highest in the youngest patients. For patients with the following PRDs, mortality was significantly higher than that in patients with primary glomerulonephritis: secondary glomerulonephritis (adjusted hazard ratio (aHR): 2.50; 95% confidence interval (CI): 1.03-6.08), urologic disorder (aHR: 4.77; 95% CI: 1.69-13.46), and metabolic diseases (aHR: 5.57; 95% CI: 1.84-16.85). Several kinds of PRDs appear to have high mortality risks in the pediatric dialysis population. These differences in mortality risk highlight the importance of the focused clinical management of these high-risk subgroups.
???metadata.dc.relation.uri???:	http://dx.doi.org/10.3390/jcm7110414
Relation:	Journal of Clinical Medicine, v.7, n.11, 414
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles

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