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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/32239

    標題: New Triterpenoid from Novel Triterpenoid 15-O-Glycosylation on Ganoderic Acid A by Intestinal Bacteria of Zebrafish
    作者: Chang, Te-Sheng
    Chiang, Chien-Min
    Wang, Tzi-Yuan
    Lee, Chun-Hsien
    Lee, Yu-Wen
    Wu, Jiumn-Yih
    貢獻者: Natl Univ Tainan, Dept Biol Sci & Technol
    Chia Nan Univ Pharm & Sci, Dept Biotechnol
    Acad Sinica, Biodivers Res Ctr
    Natl Quemoy Univ, Dept Food Sci
    關鍵字: biotransformation
    Ganoderma lucidum
    ganoderic acid A
    日期: 2018-09
    上傳時間: 2019-11-15 15:46:24 (UTC+8)
    出版者: MDPI
    摘要: Functional bacteria that could biotransform triterpenoids may exist in the diverse microflora of fish intestines. Ganoderic acid A (GAA) is a major triterpenoid from the medicinal fungus Ganoderma lucidum. In studying the microbial biotransformation of GAA, dozens of intestinal bacteria were isolated from the excreta of zebrafish. The bacteria's ability to catalyze GAA were determined using ultra-performance liquid chromatography analysis. One positive strain, GA A07, was selected for functional studies. GA A07 was confirmed as Bacillus sp., based on the DNA sequences of the 16S rRNA gene. The biotransformed metabolite was purified with the preparative high-performance liquid chromatography method and identified as GAA-15-O-beta-glucoside, based on the mass and nuclear magnetic resonance spectral data. The present study is the first to report the glycosylation of Ganoderma triterpenoids. Moreover, 15-O-glycosylation is a new microbial biotransformation of triterpenoids, and the biotransformed metabolite, GAA-15-O-beta-glucoside, is a new compound.
    link: http://dx.doi.org/10.3390/molecules23092345
    關聯: Journal of Clinical Medicine, v.23, n.9, 2345
    Appears in Collections:[生物科技系(所)] 期刊論文

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